Diacerein: Recent insight into pharmacological activities and molecular pathways

被引：71

作者：

Almezgagi, Maged ^{[1
,2
,4
]}

Zhang, Yu ^{[2
]}

Hezam, Kamal ^{[5
]}

Shamsan, Emad ^{[2
]}

Gamah, Mohammed ^{[1
,2
]}

Al-shaebi, Fadhl ^{[3
]}

Abbas, Abdul Baset ^{[4
]}

Shoaib, Muhammad ^{[2
]}

Saif, Bassam ^{[4
]}

Han, Ying ^{[1
]}

Jia, Ruhan ^{[1
]}

Zhang, Wei ^{[1
,2
]}

机构：

[1] Key Lab High Altitude Med Applicat Qinghai Prov, Xining 810001, Qinghai, Peoples R China

[2] Qinghai Univ, Dept Immunol, Med Coll, Xining 810001, Qinghai, Peoples R China

[3] Hebei Med Univ, Dept Immunol, Shijiazhuang 050017, Hebei, Peoples R China

[4] Ibb Univ, Fac Sci, Dept Med Microbiol, Ibb City 70270, Yemen

[5] Nankai Univ, Sch Med, Tianjin 300071, Peoples R China

来源：

BIOMEDICINE & PHARMACOTHERAPY | 2020年 / 131卷

基金：

中国国家自然科学基金;

关键词：

Diacerein; Anti-inflammatory; Anti-oxidant; Anti-apoptosis; Cytokines; TARGETING INFLAMMATION; INSULIN-SECRETION; GLUCOSE-TOLERANCE; THERAPEUTIC DRUG; OXIDATIVE STRESS; RHEIN LYSINATE; KIDNEY INJURY; OSTEOARTHRITIS; DIACERHEIN; MICE;

D O I：

10.1016/j.biopha.2020.110594

中图分类号：

R-3 [医学研究方法]; R3 [基础医学];

学科分类号：

1001 ;

摘要：

Diacerein is a symptomatic slow-acting drug in osteoarthritis (SYSADOA) and the active metabolite is rhein. It is a non-steroidal anti-inflammatory drug with unique pharmacological properties as anti-oxidant and anti-apoptosis. Diacerein has recently shown to have a potential role by mediating anti-inflammatory as well as antioxidant and anti-apoptosis in kidney injury, diabetes mullites, and a beneficial effect on pain relief. It may have a therapeutic role in cancer, ulcerative colitis, testicular injury and cervical hyperkeratosis. Furthermore, diacerein has a valuable addition in combination therapy as a synergetic agent. This review, the first of its kind, highlights the proposed roles of diacerein in osteoarthritis and discusses recent results supporting its emerging roles with a particular focus on how these new insights may facilitate the rational development of diacerein for targeted therapies in the future.

引用

页数：9

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