Upregulation of the CD40-CD40 ligand system in pre-eclampsia

被引:11
|
作者
Lukanov, Tzvetan Hristoforov [1 ,2 ]
Bojinova, Svetla Ivanova [3 ]
Emin, Alkan Levha [2 ]
Veleva, Galina Lubomirova [1 ]
Popova, Vanya Slavcheva [4 ]
Konova, Emiliana Ilieva [2 ]
机构
[1] Univ Hosp, Immunol Lab, Pleven 5800, Bulgaria
[2] Med Univ Pleven, Ctr Reprod Hlth, BU-5800 Pleven, Bulgaria
[3] Univ Hosp, Dept Obstet & Gynecol, Pleven, Bulgaria
[4] Univ Hosp, Dept Hematol, Pleven, Bulgaria
关键词
CD40; ligand; Flow cytometry; Inflammation; Pre-eclampsia; FLOW-CYTOMETRIC DETECTION; SOLUBLE CD40 LIGAND; PLATELET ACTIVATION; ENDOTHELIAL-CELLS; CARDIOVASCULAR-DISEASE; INFLAMMATION; CD154; WOMEN; THROMBOSIS; PREGNANCY;
D O I
10.1016/j.ijgo.2009.01.034
中图分类号
R71 [妇产科学];
学科分类号
100211 ;
摘要
Objective: To investigate the CD40-CD40 ligand (CD40L) system in women with pre-eclampsia. Methods: Expression of CD40 on monocytes and expression of CD40 and CD40L on platelets were determined by whole blood flow cytometry in 23 women with pre-eclampsia and in 23 normotensive pregnant women. Serum levels of soluble CD40L in both groups of women were measured by enzyme-linked immunosorbent assay. Results: There was a significantly higher expression of CD40 and CD40L on platelets and CD40 on monocytes in the women with pre-eclampsia compared with normotensive pregnant women (P < 0.001 for all comparisons). The serum concentration of soluble CD40L was significantly higher in women with pre-eclampsia compared with normotensive pregnant women (P = 0.012). Conclusion: Pre-eclampsia is associated with activation of the CD40-CD40L system. The activation of this system may contribute to the development or maintenance of the proinflammatory and prothrombotic responses, increased cytokine production, and endothelial cell dysfunction found in pre-eclampsia. (C) 2009 International Federation of Gynecology and Obstetrics. Published by Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:257 / 260
页数:4
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