Protective effect of light emitting diode phototherapy on fluorescent light induced retinal damage in Wistar strain albino rats

被引：6
作者：
Basha, A. Ahamed [1 ]
Mathangi, D. C. [1 ]
Shyamala, R. [1 ]
Rao, K. Ramesh [2 ]
机构：
[1] Chettinad Hosp & Res Inst, Dept Physiol, Chennai 603103, Tamil Nadu, India
[2] Chettinad Hosp & Res Inst, Dept Pathol, Chennai 603103, Tamil Nadu, India
来源：
ANNALS OF ANATOMY-ANATOMISCHER ANZEIGER | 2014年 / 196卷 / 05期
关键词：
Fluorescent light; LED phototherapy; Outer nuclear layer; Retina; INDUCED PHOTORECEPTOR DEGENERATION; IN-VIVO; GENE-EXPRESSION; BRIGHT LIGHT; RED-LIGHT; THERAPY; EXPOSURE; NIGHT; MELATONIN; PHOTOBIOMODULATION;
D O I：
10.1016/j.aanat.2014.04.004
中图分类号：
R602 [外科病理学、解剖学]; R32 [人体形态学];
学科分类号：
100101 ;
摘要：
Background: Artificial light at night alters retinal physiology. Several studies have shown that light emitting diode phototherapy protects the retina from the damaging effects of acute light exposure. Objective: The aim of this study has been to elucidate the protective effects of 670 nm LED light on retinal damage induced by chronic fluorescent light in Wistar rats. Methods: Male Wistar albino rats were divided into four groups: group 1 were control (CL), group 2,3 and 4 were exposed to fluorescent-light (FL), LED preexposure + fluorescent light exposure (LL) and only LED light exposure (OL) respectively. All animals were maintained in their specific exposure regime for 30 days. Fluorescent light of 1800 lx was exposed between 8 pm to 8 am. Rats were exposed to therapeutic LED light of 670 nm of 9 J/cm(2) at 25 mW/cm(2) for 6 min duration. Histopathological changes in the retina were studied. Results: Animals of the FL group showed a significant reduction in the outer nuclear layer thickness and cell count in addition to the total thickness of the retina. LL group which were exposed to 670 nm LED prior to exposure to fluorescent light showed a significant decrease in the degree of damage. Conclusions: 670 nm LED light preexposure is protective to retinal cells against fluorescent light-induced damage. (C) 2014 Elsevier GmbH. All rights reserved.
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页码：312 / 316
页数：5
相关论文
共 49 条
[21]   Light activates the adrenal gland: Timing of gene expression and glucocorticoid release [J].
Ishida, A ;
Mutoh, T ;
Ueyama, T ;
Bando, H ;
Masubuchi, S ;
Nakahara, D ;
Tsujimoto, G ;
Okamura, H .
CELL METABOLISM, 2005, 2 (05) :297-307
[22]   Low-Level Laser Therapy Improves Vision in a Patient with Retinitis Pigmentosa [J].
Ivandic, Boris T. ;
Ivandic, Tomislav .
PHOTOMEDICINE AND LASER SURGERY, 2014, 32 (03) :181-184
[23]   Low-Level Laser Therapy Improves Visual Acuity in Adolescent and Adult Patients with Amblyopia [J].
Ivandic, Boris T. ;
Ivandic, Tomislav .
PHOTOMEDICINE AND LASER SURGERY, 2012, 30 (03) :167-171
[24]   Alleviation of constant-light-induced photoreceptor degeneration by adaptation of adult albino rat to bright cyclic light [J].
Li, F ;
Cao, W ;
Anderson, RE .
INVESTIGATIVE OPHTHALMOLOGY & VISUAL SCIENCE, 2003, 44 (11) :4968-4975
[25]   Effects of Low-Level Light Therapy on Hepatic Antioxidant Defense in Acute and Chronic Diabetic Rats [J].
Lim, Jinhwan ;
Ali, Zeeshan M. ;
Sanders, Ruth A. ;
Snyder, Ann C. ;
Eells, Janis T. ;
Henshel, Diane S. ;
Watkins, John B., III .
JOURNAL OF BIOCHEMICAL AND MOLECULAR TOXICOLOGY, 2009, 23 (01) :1-8
[26]   Melatonin Secretion and the Incidence of Type 2 Diabetes [J].
McMullan, Ciaran J. ;
Schernhammer, Eva S. ;
Rimm, Eric B. ;
Hu, Frank B. ;
Forman, John P. .
JAMA-JOURNAL OF THE AMERICAN MEDICAL ASSOCIATION, 2013, 309 (13) :1388-1396
[27]  
Miyauchi F, 1990, Nihon Naibunpi Gakkai Zasshi, V66, P737
[28]   A neural mechanism for exacerbation of headache by light [J].
Noseda, Rodrigo ;
Kainz, Vanessa ;
Jakubowski, Moshe ;
Gooley, Joshua J. ;
Saper, Clifford B. ;
Digre, Kathleen ;
Burstein, Rami .
NATURE NEUROSCIENCE, 2010, 13 (02) :239-U128
[29]   Retinal light damage: Mechanisms and protection [J].
Organisciak, Daniel T. ;
Vaughan, Dana K. .
PROGRESS IN RETINAL AND EYE RESEARCH, 2010, 29 (02) :113-134
[30]  
ORGANISCIAK DT, 1985, INVEST OPHTH VIS SCI, V26, P1580
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