MiR-200, a new star miRNA in human cancer

被引：305

作者：

Feng, Xiangling ^{[1
]}

Wang, Zhengming ^{[1
]}

Fillmore, Rebecca ^{[2
]}

Xi, Yaguang ^{[1
]}

机构：

[1] Univ S Alabama, Mitchell Canc Inst, Mobile, AL 36604 USA

[2] Univ Southern Mississippi Gulf Coast, Dept Biol Sci, Long Beach, MS USA

来源：

CANCER LETTERS | 2014年 / 344卷 / 02期

关键词：

MicroRNA; MiR-200; EMT; Stem cells; ZEB; Cell cycle; EPITHELIAL-MESENCHYMAL TRANSITION; NEGATIVE FEEDBACK LOOP; BREAST-CANCER; DOWN-REGULATION; RNA-INTERFERENCE; NUCLEAR EXPORT; E-CADHERIN; REGULATED MICRORNAS; PANCREATIC-CANCER; OXIDATIVE STRESS;

D O I：

10.1016/j.canlet.2013.11.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are a set of non-coding small RNA molecules in control of gene expression at posttranscriptional/translational level. They not only play crucial roles in normal developmental progress, but also are commonly dysregulated in human diseases, including cancer. MiR-200 is a family of tumor suppressor miRNAs consisting of five members, which are significantly involved in inhibition of epithelial-to-mesenchymal transition (EMT), repression of cancer stem cells (CSCs) self-renewal and differentiation, modulation of cell division and apoptosis, and reversal of chemoresistance. In this article, we summarize the latest findings with regard to the tumor suppressor signatures of miR-200 and the regulatory mechanisms of miR-200 expression. The collected evidence supports that miR-200 is becoming a new star miRNA in study of human cancer. Published by Elsevier Ireland Ltd.

引用

页码：166 / 173

页数：8

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