MiR-200, a new star miRNA in human cancer

被引：305

作者：

Feng, Xiangling ^{[1
]}

Wang, Zhengming ^{[1
]}

Fillmore, Rebecca ^{[2
]}

Xi, Yaguang ^{[1
]}

机构：

[1] Univ S Alabama, Mitchell Canc Inst, Mobile, AL 36604 USA

[2] Univ Southern Mississippi Gulf Coast, Dept Biol Sci, Long Beach, MS USA

来源：

CANCER LETTERS | 2014年 / 344卷 / 02期

关键词：

MicroRNA; MiR-200; EMT; Stem cells; ZEB; Cell cycle; EPITHELIAL-MESENCHYMAL TRANSITION; NEGATIVE FEEDBACK LOOP; BREAST-CANCER; DOWN-REGULATION; RNA-INTERFERENCE; NUCLEAR EXPORT; E-CADHERIN; REGULATED MICRORNAS; PANCREATIC-CANCER; OXIDATIVE STRESS;

D O I：

10.1016/j.canlet.2013.11.004

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

MicroRNAs (miRNAs) are a set of non-coding small RNA molecules in control of gene expression at posttranscriptional/translational level. They not only play crucial roles in normal developmental progress, but also are commonly dysregulated in human diseases, including cancer. MiR-200 is a family of tumor suppressor miRNAs consisting of five members, which are significantly involved in inhibition of epithelial-to-mesenchymal transition (EMT), repression of cancer stem cells (CSCs) self-renewal and differentiation, modulation of cell division and apoptosis, and reversal of chemoresistance. In this article, we summarize the latest findings with regard to the tumor suppressor signatures of miR-200 and the regulatory mechanisms of miR-200 expression. The collected evidence supports that miR-200 is becoming a new star miRNA in study of human cancer. Published by Elsevier Ireland Ltd.

引用

页码：166 / 173

页数：8

共 107 条

[1] miR-200 Expression Regulates Epithelial-to-Mesenchymal Transition in Bladder Cancer Cells and Reverses Resistance to Epidermal Growth Factor Receptor Therapy [J].

Adam, Liana ;

Zhong, Meng ;

Choi, Woonyoung ;

Qi, Wei ;

Nicoloso, Milena ;

Arora, Ameeta ;

Calin, George ;

Wang, Hua ;

Siefker-Radtke, Arlene ;

McConkey, David ;

Bar-Eli, Menashe ;

Dinney, Colin .

CLINICAL CANCER RESEARCH, 2009, 15 (16) :5060-5072

[2] Smad3 regulates E-cadherin via miRNA-200 pathway [J].

Ahn, S-M ;

Cha, J-Y ;

Kim, J. ;

Kim, D. ;

Trang, H. T. H. ;

Kim, Y-M ;

Cho, Y-H ;

Park, D. ;

Hong, S. .

ONCOGENE, 2012, 31 (25) :3051-3059

[3] RETRACTED: Gemcitabine Sensitivity Can Be Induced in Pancreatic Cancer Cells through Modulation of miR-200 and miR-21 Expression by Curcumin or Its Analogue CDF (Retracted article. See vol. 78, pg. 5466, 2018) [J].

Ali, Shadan ;

Ahmad, Aamir ;

Banerjee, Sanjeev ;

Padhye, Subhash ;

Dominiak, Kristin ;

Schaffert, Jacqueline M. ;

Wang, Zhiwei ;

Philip, Philip A. ;

Sarkar, Fazlul H. .

CANCER RESEARCH, 2010, 70 (09) :3606-3617

[4] microRNAs: Tiny regulators with great potential [J].

Ambros, V .

CELL, 2001, 107 (07) :823-826

[5] MicroRNA-200 Family Modulation in Distinct Breast Cancer Phenotypes [J].

Angeles Castilla, Maria ;

Diaz-Martin, Juan ;

Sarrio, David ;

Romero-Perez, Laura ;

Angeles Lopez-Garcia, Maria ;

Vieites, Begona ;

Biscuola, Michele ;

Ramiro-Fuentes, Susana ;

Isacke, Clare M. ;

Palacios, Jose .

PLOS ONE, 2012, 7 (10)

[6] MicroRNA-regulated gene networks during mammary cell differentiation are associated with breast cancer [J].

Aydogdu, Eylem ;

Katchy, Anne ;

Tsouko, Efrosini ;

Lin, Chin-Yo ;

Haldosen, Lars-Arne ;

Helguero, Luisa ;

Williams, Cecilia .

CARCINOGENESIS, 2012, 33 (08) :1502-1511

[7] Tamoxifen Represses miR-200 MicroRNAs and Promotes Epithelial-to-Mesenchymal Transition by Up-Regulating c-Myc in Endometrial Carcinoma Cell Lines [J].

Bai, Jiu-Xu ;

Yan, Bo ;

Zhao, Zhi-Ning ;

Xiao, Xiao ;

Qin, Wei-Wei ;

Zhang, Rui ;

Jia, Lin-Tao ;

Meng, Yan-Ling ;

Jin, Bo-Quan ;

Fan, Dai-Ming ;

Wang, Tao ;

Yang, An-Gang .

ENDOCRINOLOGY, 2013, 154 (02) :635-645

[8] Biochemical relapse following radical prostatectomy and miR-200a levels in prostate cancer [J].

Barron, Niall ;

Keenan, Joanne ;

Gammell, Patrick ;

Martinez, Vanesa G. ;

Freeman, Alex ;

Masters, John R. ;

Clynes, Martin .

PROSTATE, 2012, 72 (11) :1193-1199

[9] MicroRNAs: Genomics, biogenesis, mechanism, and function (Reprinted from Cell, vol 116, pg 281-297, 2004) [J].

Bartel, David P. .

CELL, 2007, 131 (04) :11-29

[10] Regulation of miR-200 family microRNAs and ZEB transcription factors in ovarian cancer: Evidence supporting a mesothelial-to-epithelial transition [J].

Bendoraite, Ausra ;

Knouf, Emily C. ;

Garg, Kavita S. ;

Parkin, Rachael K. ;

Kroh, Evan M. ;

O'Briant, Kathy C. ;

Ventura, Aviva P. ;

Godwin, Andrew K. ;

Karlan, Beth Y. ;

Drescher, Charles W. ;

Urban, Nicole ;

Knudsen, Beatrice S. ;

Tewari, Muneesh .

GYNECOLOGIC ONCOLOGY, 2010, 116 (01) :117-125

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