Role of tumor microenvironment in tumorigenesis

被引：1049

作者：

Wang, Maonan ^{[1
,2
]}

Zhao, Jingzhou ^{[2
]}

Zhang, Lishen ^{[2
]}

Wei, Fang ^{[2
]}

Lian, Yu ^{[2
]}

Wu, Yingfeng ^{[2
]}

Gong, Zhaojian ^{[2
]}

Zhang, Shanshan ^{[1
]}

Zhou, Jianda ^{[3
]}

Cao, Ke ^{[3
]}

Li, Xiayu ^{[3
]}

Xiong, Wei ^{[1
,2
,3
]}

Li, Guiyuan ^{[1
,2
,3
]}

Zeng, Zhaoyang ^{[1
,2
,3
]}

Guo, Can ^{[1
,2
,3
]}

机构：

[1] Cent S Univ, Xiangya Hosp, Key Lab Carcinogenesis, Minist Hlth, Changsha 410078, Hunan, Peoples R China

[2] Cent S Univ, Canc Res Inst, Key Lab Carcinogenesis & Canc Invas, Minist Educ, Changsha 410078, Hunan, Peoples R China

[3] Cent S Univ, Xiangya Hosp 3, Dis Genome Res Ctr, Hunan Key Lab Nonresolving Inflammat & Canc, Changsha 410013, Hunan, Peoples R China

来源：

JOURNAL OF CANCER | 2017年 / 8卷 / 05期

基金：

中国国家自然科学基金;

关键词：

cancer-associated fibroblasts (CAFs); neuroendocrine cells; adipose cells; immune-inflammatory cells; angiogenesis; ENDOTHELIAL-GROWTH-FACTOR; EPITHELIAL-MESENCHYMAL TRANSITION; CANCER-ASSOCIATED FIBROBLASTS; REGULATORY T-CELLS; PANCREATIC DUCTAL ADENOCARCINOMA; CANDIDATE MOLECULAR MARKERS; MECHANISMS LINKING OBESITY; LYMPH-NODE METASTASIS; LONG NONCODING RNAS; NF-KAPPA-B;

D O I：

10.7150/jca.17648

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Tumorigenesis is a complex and dynamic process, consisting of three stages: initiation, progression, and metastasis. Tumors are encircled by extracellular matrix (ECM) and stromal cells, and the physiological state of the tumor microenvironment (TME) is closely connected to every step of tumorigenesis. Evidence suggests that the vital components of the TME are fibroblasts and myofibroblasts, neuroendocrine cells, adipose cells, immune and inflammatory cells, the blood and lymphatic vascular networks, and ECM. This manuscript, based on the current studies of the TME, offers a more comprehensive overview of the primary functions of each component of the TME in cancer initiation, progression, and invasion. The manuscript also includes primary therapeutic targeting markers for each player, which may be helpful in treating tumors.

引用

页码：761 / 773

页数：13

共 276 条

[1] Crystallization and preliminary X-ray diffraction analysis of three EGF domains of EMR2, a 7TM immune-system molecule [J].

Abbott, RJM ;

Knott, V ;

Roversi, P ;

Neudeck, S ;

Lukacik, P ;

Handford, PA ;

Lea, SM .

ACTA CRYSTALLOGRAPHICA SECTION D-STRUCTURAL BIOLOGY, 2004, 60 :936-938

[2] IFATS Collection: The Role of Human Adipose-Derived Stromal Cells in Inflammatory Microvascular Remodeling and Evidence of a Perivascular Phenotype [J].

Amos, Peter J. ;

Shang, Hulan ;

Bailey, Alexander M. ;

Taylor, Alyssa ;

Katz, Adam J. ;

Peirce, Shayn M. .

STEM CELLS, 2008, 26 (10) :2682-2690

[3] From the immune contexture to the Immunoscore: the role of prognostic and predictive immune markers in cancer [J].

Angel, Helen ;

Galon, Jerome .

CURRENT OPINION IN IMMUNOLOGY, 2013, 25 (02) :261-267

[4]

[Anonymous], 2014, BIOSCI REP

[5] Silencing of miR-148a in cancer-associated fibroblasts results in WNT10B-mediated stimulation of tumor cell motility [J].

Aprelikova, O. ;

Palla, J. ;

Hibler, B. ;

Yu, X. ;

Greer, Y. E. ;

Yi, M. ;

Stephens, R. ;

Maxwell, G. L. ;

Jazaeri, A. ;

Risinger, J. I. ;

Rubin, J. S. ;

Niederhuber, J. .

ONCOGENE, 2013, 32 (27) :3246-3253

[6] IL-1β regulates blood-brain barrier permeability via reactivation of the hypoxia-angiogenesis program [J].

Argaw, Azeb Tadesse ;

Zhang, Yueting ;

Snyder, Brian J. ;

Zhao, Meng-Liang ;

Kopp, Natalya ;

Lee, Sunhee C. ;

Raine, Cedric S. ;

Brosnan, Celia F. ;

John, Gareth R. .

JOURNAL OF IMMUNOLOGY, 2006, 177 (08) :5574-5584

[7] Cancer-Related Axonogenesis and Neurogenesis in Prostate Cancer [J].

Ayala, Gustavo E. ;

Dai, Hong ;

Powell, Michael ;

Li, Rile ;

Ding, Yi ;

Wheeler, Thomas M. ;

Shine, David ;

Kadmon, Dov ;

Thompson, Timothy ;

Miles, Brian J. ;

Ittmann, Michael M. ;

Rowley, David .

CLINICAL CANCER RESEARCH, 2008, 14 (23) :7593-7603

[8] Human T lymphocytes are direct targets of 1,25-dihydroxyvitamin D3 in the immune system [J].

Baeke, Femke ;

Korf, Hannelie ;

Overbergh, Lut ;

van Etten, Evelyne ;

Verstuyf, Annemieke ;

Gysemans, Conny ;

Mathieu, Chantal .

JOURNAL OF STEROID BIOCHEMISTRY AND MOLECULAR BIOLOGY, 2010, 121 (1-2) :221-227

[9] LYVE-1, a new homologue of the CD44 glycoprotein, is a lymph-specific receptor for hyaluronan [J].

Banerji, S ;

Ni, J ;

Wang, SX ;

Clasper, S ;

Su, J ;

Tammi, R ;

Jones, M ;

Jackson, DG .

JOURNAL OF CELL BIOLOGY, 1999, 144 (04) :789-801

[10] OXYGEN-PRESSURE IN SMALL LYMPHATICS [J].

BARANKAY, T ;

BAUMGARTL, H ;

LUBBERS, DW ;

SEIDL, E .

PFLUGERS ARCHIV-EUROPEAN JOURNAL OF PHYSIOLOGY, 1976, 366 (01) :53-59

← 1 2 3 4 5 6 7 8 9 10 →