PTHrP-producing tumor: Squamous cell carcinoma of the liver accompanied by humoral hypercalcemia of malignancy, increased IL-6 and leukocytosis

被引：6

作者：

Asanuma, N ^{[1
]}

Hagiwara, K ^{[1
]}

Matsumoto, I ^{[1
]}

Matsuda, M ^{[1
]}

Nakamura, F ^{[1
]}

Kouhara, H ^{[1
]}

Miyamoto, M ^{[1
]}

Miyashita, Y ^{[1
]}

Noguchi, S ^{[1
]}

Morimoto, Y ^{[1
]}

机构：

[1] Aizenbashi Hosp, Dept Internal Med, Osaka, Japan

来源：

INTERNAL MEDICINE | 2002年 / 41卷 / 05期

关键词：

calcium; parathyroid hormone; cytokine; liver cyst;

D O I：

10.2169/internalmedicine.41.371

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

A 77-year-old man was admitted to our hospital showing symptoms of general fatigue and appetite loss. He had leukocytosis, thrombocytosis and hypercalcemia with elevated serum levels of parathyroid hormone related peptide (PTHrP) and interleukin-6 (IL-6). An increase in tumor markers SCC and CYFURA21-1 was observed. The liver contained a huge tumor, which was proved to be PTHrP producing squamous cell carcinoma by immuno-histochemical analysis. Since the tumor did not express IL-6, it was assumed to be induced by PTHrP in osteoblasts. This is the first report of PTHrP producing squamous cell carcinoma of the liver.

引用

页码：371 / 376

页数：6

共 32 条

[1]

ARASE Y, 1988, ACTA PATHOL JAPON, V38, P643

[2] Coordinated cytokine expression by stromal and hematopoietic cells during human osteoclast formation [J].

Atkins, GJ ;

Haynes, DR ;

Geary, SM ;

Loric, M ;

Crotti, TN ;

Findlay, DM .

BONE, 2000, 26 (06) :653-661

[3]

BANBURY J, 1994, J SURG ONCOL, V57, P210

[4]

BLOUSTEIN PA, 1976, CANCER, V38, P2002, DOI 10.1002/1097-0142(197611)38:5<2002::AID-CNCR2820380523>3.0.CO

[5]

2-9

[6]

BROADUS AE, 1988, NEW ENGL J MED, V319, P556

[7] IMMUNOCHEMICAL CHARACTERIZATION OF CIRCULATING PARATHYROID-HORMONE RELATED PROTEIN IN PATIENTS WITH HUMORAL HYPERCALCEMIA OF CANCER [J].

BURTIS, WJ ;

BRADY, TG ;

ORLOFF, JJ ;

ERSBAK, JB ;

WARRELL, RP ;

OLSON, BR ;

WU, TL ;

MITNICK, ME ;

BROADUS, AE ;

STEWART, AF .

NEW ENGLAND JOURNAL OF MEDICINE, 1990, 322 (16) :1106-1112

[8]

CHAUDHURI PK, 1982, ARCH SURG-CHICAGO, V117, P1349

[9] SQUAMOUS CARCINOMA IN THE LIVER [J].

CLEMENTS, D ;

NEWMAN, P ;

ETHERINGTON, R ;

LAWRIE, BW ;

RHODES, J .

GUT, 1990, 31 (11) :1333-1334

[10]

DANKS JA, 1989, J BONE MINER RES, V4, P273

← 1 2 3 4 →