Axon degeneration: Linking axonal bioenergetics to myelin

被引：5

作者：

Beirowski, Bogdan ^{[1
]}

Babetto, Elisabetta ^{[1
]}

Wrabetz, Lawrence ^{[1
]}

机构：

[1] SUNY Buffalo, Hunter James Kelly Res Inst, Jacobs Sch Med & Biomed Sci, Buffalo, NY 14203 USA

来源：

JOURNAL OF CELL BIOLOGY | 2016年 / 215卷 / 04期

关键词：

PROTEIN; SUPPORT; LACKING;

D O I：

10.1083/jcb.201611010

中图分类号：

Q2 [细胞生物学];

学科分类号：

071009 ; 090102 ;

摘要：

The mechanisms by which axonal degeneration occurs, even in the presence of apparently normal myelin sheaths, remain unknown. In this issue, Yin et al. (2016. J. Cell Biol. https://doi.org/10.1083/jcb.201607099) study mutant mice in which proteolipid protein is replaced by the peripheral myelin protein P-0 and describe a number of early axonal abnormalities, which together suggest that aberrant mitochondrial energy metabolism precedes axonal degeneration.

引用

页码：437 / 440

页数：4

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