Ester-mediated peptide formation promoted by deep eutectic solvents: a facile pathway to proto-peptides

被引：11

作者：

Chien, Chen-Yu ^{[1
]}

Yu, Sheng-Sheng ^{[1
]}

机构：

[1] Natl Cheng Kung Univ, Dept Chem Engn, 1 Univ Rd, Tainan 70101, Taiwan

来源：

CHEMICAL COMMUNICATIONS | 2020年 / 56卷 / 80期

关键词：

AMINO-ACIDS; CONDENSATION; PHOSPHATE;

D O I：

10.1039/d0cc03319g

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The ester-amide exchange reaction enables spontaneous formation of prebiotic proto-peptides under mild conditions. However, this reaction also leads to oligomers with a vast sequence diversity of ester and amide linkages. Here, we demonstrate using deep eutectic solvents as a universal strategy to regulate the reaction pathways and promote the formation of amino acid-enriched oligomers with peptide backbones.

引用

页码：11949 / 11952

页数：4

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