α-synuclein and the pathogenesis of Parkinson's disease

被引：25
作者：
Martin, FL [1 ]
Williamson, SJM [1 ]
Paleologou, KE [1 ]
Allsop, D [1 ]
El-Agnaf, OMA [1 ]
机构：
[1] Univ Lancaster, IENS, Dept Biol Sci, Lancaster LA1 4YQ, England
来源：
PROTEIN AND PEPTIDE LETTERS | 2004年 / 11卷 / 03期
关键词：
Parkinson's disease; DNA single-strand breaks; Fe(II); alpha-synuclein; Comet assay; comet tail length; reactive oxygen species; environmental causation;
D O I：
10.2174/0929866043407138
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Lesions known as Lewy bodies (LBs) and Lewy neurites (LNs) characterise brains of Parkinson's disease (PD) patients. Intracellular aggregation of alpha-synuclein (alpha-syn) appears to play a key role in the generation of LBs and LNs. Such aggregation in the presence of redox metals may initiate Fenton reaction-mediated generation of reactive oxygen species (ROS). ROS thus generated may result in cytotoxic mechanisms such as the induction of DNA single-strand breaks.
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收藏
页码：229 / 237
页数：9
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