Push-Pull Mechanism for Lipid Raft Formation

被引：33

作者：

Krause, Martin R. ^{[1
]}

Daly, Trevor A. ^{[1
]}

Almeida, Paulo F. ^{[2
]}

Regen, Steven L. ^{[1
]}

机构：

[1] Lehigh Univ, Dept Chem, Bethlehem, PA 18015 USA

[2] Univ N Carolina, Dept Chem & Biochem, Wilmington, NC 28403 USA

来源：

LANGMUIR | 2014年 / 30卷 / 12期

基金：

美国国家科学基金会;

关键词：

NEAREST-NEIGHBOR RECOGNITION; CHOLESTEROL; PHASE; BILAYERS; MODEL; PHOSPHOLIPIDS; MEMBRANES; BEHAVIOR; DOMAINS; ORDER;

D O I：

10.1021/la500510s

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A quantitative assessment has been made of the interaction between exchangeable mimics of 1-palmitoyl-2-oleoyl-sn-glycero-3-phosphocholine (POPC) and cholesterol in the liquid-ordered (l(0)) and the liquid-disordered (l(d)) states using the nearest-neighbor recognition (NNR) method. This assessment has established that these lipids mix ideally in the l(0) phase (i.e., they show no net attraction or repulsion toward each other) but exhibit repulsive interactions in the l(d) phase. The implications of these findings for the interactions between unsaturated phospholipids and cholesterol in eukaryotic cell membranes are briefly discussed.

引用

页码：3285 / 3289

页数：5

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