Behavioral effects of perinatal opioid exposure

被引:45
作者
Fodor, Anna [1 ,2 ]
Timar, Julia [3 ]
Zelena, Dora [1 ]
机构
[1] Hungarian Acad Sci, Inst Expt Med, H-1083 Budapest, Hungary
[2] Semmelweis Univ, Janos Szentagothai Sch Neurosci, H-1085 Budapest, Hungary
[3] Semmelweis Univ, Dept Pharmacol & Pharmacotherapy, H-1085 Budapest, Hungary
关键词
Morphine; Methadone; Pain killer; Street drug; Gender difference; Stress; PRENATAL MORPHINE EXPOSURE; ADULT FEMALE RATS; MATERNAL-BEHAVIOR; SEIZURE SUSCEPTIBILITY; BRAIN-DEVELOPMENT; OPIATE EXPOSURE; SEXUAL-BEHAVIOR; NEGATIVE FEEDBACK; NEONATAL OUTCOMES; ENHANCES COCAINE;
D O I
10.1016/j.lfs.2014.04.006
中图分类号
R-3 [医学研究方法]; R3 [基础医学];
学科分类号
1001 ;
摘要
Opioids are among the world's oldest known drugs used mostly for pain relief, but recreational use is also widespread. A particularly important problem is opioid exposure in females, as their offspring can also be affected. Adverse intrauterine and postnatal environments can affect offspring development and may lead to various disabilities later in life. It is clear that repetitive painful experiences, such as randomly occurring invasive procedures during neonatal intensive care, can permanently alter neuronal and synaptic organization and therefore later behavior. At the same time, analgesic drugs can also be harmful, inducing neuronal apoptosis or withdrawal symptoms in the neonate and behavioral alterations in adulthood. Hence, rislc-benefit ratios should be taken into consideration when pain relief is required during pregnancy or in neonates. Recreational use of opioids can also alter many aspects of life. Intrauterine opioid exposure has many toxic effects, inducing poor pregnancy outcomes due to underdevelopment, but it is believed that later negative consequences are more related to environmental factors such as a chaotic lifestyle and inadequate prenatal care. One of the crucial components is maternal care, which changes profoundly in addicted mothers. In substance-dependent mothers, pre- and postnatal care has special importance, and controlled treatment with a synthetic opioid (e.g., methadone) could be beneficial. We aimed to summarize and compare human and rodent data, as it is important to close the gap between scientific knowledge and societal policies. Special emphasis is given to gender differences in the sensitivity of offspring to perinatal opioid exposure. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码:1 / 8
页数:8
相关论文
共 123 条
  • [1] EFFECTS OF MORPHINE, PENTOBARBITAL AND AMPHETAMINE ON FORMALIN-INDUCED BEHAVIORS IN INFANT RATS - SEDATION VERSUS SPECIFIC SUPPRESSION OF PAIN
    ABBOTT, FV
    GUY, ER
    [J]. PAIN, 1995, 62 (03) : 303 - 312
  • [2] Pharmacological therapy for analgesia and sedation in the newborn
    Anand, K. J. S.
    Hall, R. W.
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2006, 91 (06): : F448 - F453
  • [3] Anand KJS, 2000, PROG BRAIN RES, V122, P117
  • [4] MATERNAL AND NEONATAL FENTANYL AND BUPIVACAINE CONCENTRATIONS AFTER EPIDURAL INFUSION DURING LABOR
    BADER, AM
    FRAGNETO, R
    TERUI, K
    ARTHUR, GR
    LOFERSKI, B
    DATTA, S
    [J]. ANESTHESIA AND ANALGESIA, 1995, 81 (04) : 829 - 832
  • [5] Morphine-enhanced apoptosis in selective brain regions of neonatal rats
    Bajic, Dusica
    Commons, Kathryn G.
    Soriano, Sulpicio G.
    [J]. INTERNATIONAL JOURNAL OF DEVELOPMENTAL NEUROSCIENCE, 2013, 31 (04) : 258 - 266
  • [6] BASHORE RA, 1981, WESTERN J MED, V134, P506
  • [7] Opioids for neonates receiving mechanical ventilation: a systematic review and meta-analysis
    Bellu, R.
    de Waal, Koert
    Zanini, R.
    [J]. ARCHIVES OF DISEASE IN CHILDHOOD-FETAL AND NEONATAL EDITION, 2010, 95 (04): : F241 - F251
  • [8] Interactions of inflammatory pain and morphine in infant rats - Long-term behavioral effects
    Bhutta, AT
    Rovnaghi, C
    Simpson, PM
    Gossett, JM
    Scalzo, FM
    Anand, KJS
    [J]. PHYSIOLOGY & BEHAVIOR, 2001, 73 (1-2) : 51 - 58
  • [9] Bhuvaneswar Chaya G, 2008, Prim Care Companion J Clin Psychiatry, V10, P59
  • [10] Update on the pharmacologic management of neonatal abstinence syndrome
    Bio, L. L.
    Siu, A.
    Poon, C. Y.
    [J]. JOURNAL OF PERINATOLOGY, 2011, 31 (11) : 692 - 701