ASSOCIATION BETWEEN INTERLEUKIN-10 GENE (-1082G/A) POLYMORPHISM AND TYPE 2 DIABETES, DIABETES-RELATED TRAITS, AND MICROVASCULAR COMPLICATIONS IN THE CROATIAN POPULATION

被引：11

作者：

Canecki-Varzic, Silvija ^{[1
]}

Prpic-Krizevac, Ivana ^{[1
]}

Mihaljevic, Silvio ^{[2
]}

Bilic-Curcic, Ines ^{[1
]}

Alkhamis, Tamara ^{[3
]}

Wagner, Jasenka ^{[4
]}

Skrlec, Ivana ^{[4
,5
]}

Barbic, Jerko ^{[3
,6
]}

机构：

[1] Josip Juraj Strossmayer Univ Osijek, Osijek Univ Hosp Ctr, Fac Med, Dept Diabet Endocrinol & Metab Disorders, J Huttlera 4, HR-31000 Osijek, Croatia

[2] Josip Juraj Strossmayer Univ Osijek, Osijek Univ Hosp Ctr, Fac Med, Dept Gastroenterol & Hepatol, Osijek, Croatia

[3] Josip Juraj Strossmayer Univ Osijek, Fac Med, Dept Pathophysiol, Osijek, Croatia

[4] Josip Juraj Strossmayer Univ Osijek, Fac Med, Dept Med Biol & Genet, Osijek, Croatia

[5] Josip Juraj Strossmayer Univ Osijek, Fac Dent Med & Hlth, Osijek, Croatia

[6] Josip Juraj Strossmayer Univ Osijek, Osijek Univ Hosp Ctr, Fac Med, Dept Nephrol & Dialysis, Osijek, Croatia

来源：

ACTA CLINICA CROATICA | 2018年 / 57卷 / 01期

关键词：

Type; 2; diabetes; Inflammation; Interleukin-10; Single nucleotide polymorphism-1082G/A; Microvascular complications; NECROSIS-FACTOR-ALPHA; ACUTE-PHASE PROTEINS; INSULIN-RESISTANCE; METABOLICALLY HEALTHY; ATHEROSCLEROSIS RISK; ADIPONECTIN GENE; INFLAMMATION; MELLITUS; ADULTS; COMMUNITIES;

D O I：

10.20471/acc.2018.57.01.08

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Interleukin (IL)-10 is an anti-inflammatory cytokine, and a decrease in its secretion is associated with obesity, metabolic syndrome and type 2 diabetes. However, it has not been established whether the intensity of the immune response during diabetes-associated chronic inflammation affects the development and/or progression of type 2 diabetes and its microvascular complications. The aim of this study was to investigate the role of single nucleotide polymorphism (SNP)-1082G/A for IL-10 gene in development of diabetes type 2 and its complications. DNA was extracted from blood cells of 240 overweight/obese subjects for IL-10 genotyping. Based on the presence of diabetes type 2, patients were divided in two groups: experimental group of 144 patients with diabetes type 2 and control group of 96 age- and gender-matched subjects without diabetes. Compared to control group, diabetic group had higher levels of leukocytes (p=0.012), fibrinogen (p=0.049) and plasminogen activator inhibitor-1 (PAI-1) (p=0.009), and lower levels of albumin (p=0.001). There were no differences in the frequency of SNP-1082G/A for IL-10 gene between the two groups (p=0.654). When considering diabetes related traits in all subjects in relation to specific genotype, a group with homozygous (AA) genotype had higher values of the mean fasting glucose (p<0.000001), HbA1c (p<0.000001) and HOMA-IR (p=0.003632), while the mean HOMA-B value (p=0.000178) was lower when compared to the groups with GG and GA genotypes. There was no difference in development of diabetic nephropathy, retinopathy and polyneuropathy between the IL-10 polymorphism genotypes. In conclusion, obese diabetes type 2 patients had an increased inflammation activity compared to obese non-diabetic individuals. "There was no association of the investigated polymorphisms and development of type 2 diabetes and its microvascular complications. However, diabetes related traits clearly depended on the presence of specific IL-10 genotype.

引用

页码：71 / 81

页数：11