Pharyngeal carriage of Neisseria meningitidis in 2-19-year-old individuals in Uganda

被引：17

作者：

Caugant, Dominique A.

Fogg, Carole

Bajunirwe, Francis

Piola, Patrice

Twesigye, Rogers

Mutebi, Fred

Froholm, L. Oddvar

Rosenqvist, Einar

Batwala, Vincent

Aaberge, Ingeborg S.

Rottingen, John-Arne

Guerin, Philippe J.

机构：

[1] Norwegian Inst Publ Hlth, Dept Airborne Infect, Div Infect Dis Control, WHO Collaborating Ctr Reference & Res Meningococc, NO-0403 Oslo, Norway

[2] Univ Oslo, Dept Oral Biol, N-0317 Oslo, Norway

[3] Univ Oslo, Ctr Prevent Global Infect, N-0317 Oslo, Norway

[4] Epictr, F-75004 Paris, France

[5] Mbarara Univ Sci & Technol, Mbarara, Uganda

[6] Norwegian Knowledge Ctr Hlth Serv, N-0130 Oslo, Norway

来源：

TRANSACTIONS OF THE ROYAL SOCIETY OF TROPICAL MEDICINE AND HYGIENE | 2006年 / 100卷 / 12期

关键词：

Neisseria meningitidis; meningococcal carriage; serogroup W135; Uganda;

D O I：

10.1016/j.trstmh.2006.01.004

中图分类号：

R1 [预防医学、卫生学];

学科分类号：

1004 ; 120402 ;

摘要：

In southern Uganda, only sporadic cases of serogroup A meningococcal disease have been reported since 2000. As part of an immunogenicity study of the tetravalent meningococcal polysaccharide vaccine, nasopharyngeal swab samples were collected twice, 4 weeks apart, from 2-19-year-old healthy individuals in Mbarara, Uganda. Only 15 (2.0%) of the 750 individuals carried meningococci asymptomatically. Most of the strains were non-serogroupable and none were serogroup A. However, two individuals carried a serogroup W135 strain, sequence type (ST)-11, similar to the clone that was responsible for the epidemic in Burkina Faso in 2002. Our study further demonstrates the geographical spread of serogroup W135 ST-11 strain and thus the potential epidemic risk. (C) 2006 Royal Society of Tropical Medicine and Hygiene. Published by Elsevier Ltd. All rights reserved.

引用

页码：1159 / 1163

页数：5

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