Computer-Assisted Three-Dimensional Analysis of Multifocal/Multicentric Prostate Cancer

被引：1

作者：

Fujii, Tomomi ^{[1
]}

Ishida, Eiwa ^{[2
]}

Shimada, Keiji ^{[1
]}

Hirao, Kazuya ^{[3
]}

Tanaka, Nobumichi ^{[4
]}

Fujimoto, Kiyohide ^{[4
]}

Konishi, Noboru ^{[1
]}

机构：

[1] Nara Med Univ, Sch Med, Dept Pathol, Kashihara, Nara 6348521, Japan

[2] West Japan Railway Co, Osaka Gen Hosp, Dept Pathol, Osaka, Japan

[3] Hirao Hosp, Dept Urol, Nara, Japan

[4] Nara Med Univ, Sch Med, Dept Urol, Kashihara, Nara 6348521, Japan

来源：

CANCER INVESTIGATION | 2014年 / 32卷 / 07期

关键词：

Bladder & prostate cancer; Carcinogenesis; Tumor imaging; PAPILLARY THYROID-CARCINOMA; INTRAEPITHELIAL NEOPLASIA; INTRADUCTAL CARCINOMA; TUMOR FOCI; GRADE; PRECURSOR; ADENOCARCINOMA; HETEROGENEITY; INVOLVEMENT; SPECIMENS;

D O I：

10.3109/07357907.2014.911878

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

In order to study multiple contiguous prostate cancer lesions, we constructed computer-assisted, three-dimensional models of multifocal prostate cancer specimens obtained by radical prostatectomy. We then examined the genetic heterogeneity among the specimens by DNA microarray analysis. Cancer foci with high Gleason patterns were found to occur de novo, whereas those with low Gleason patterns occurred contiguously with cancers of low Gleason patterns. Three-dimensional analysis showed that distinct, noncontiguous cancerous foci were genetically independent andmulticentric. In contrast some contiguous multifocal lesions had the same genetic origin.

引用

页码：303 / 310

页数：8

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