Network Protein Interaction in Parkinson's Disease and Periodontitis Interplay: A Preliminary Bioinformatic Analysis

被引：9

作者：

Botelho, Joao ^{[1
,2
]}

Mascarenhas, Paulo ^{[2
,3
]}

Mendes, Jose Joao ^{[2
]}

Machado, Vanessa ^{[1
,2
]}

机构：

[1] Inst Univ Egas Moniz IUEM, Ctr Invest Interdisciplinar Egas Moniz CiiEM, Clin Res Unit CRU, Periodontol Dept, P-2829511 Caparica, Portugal

[2] Inst Univ Egas Moniz IUEM, Ctr Invest Interdisciplinar Egas Moniz CiiEM, Clin Res Unit CRU, Evidence Based Hub, P-2829511 Caparica, Portugal

[3] Inst Univ Egas Moniz IUEM, Ctr Med Genet & Pediat Nutr Egas Moniz, P-2829511 Caparica, Portugal

来源：

GENES | 2020年 / 11卷 / 11期

关键词：

Parkinson’ s disease; periodontitis; periodontal disease; protein– protein network interaction; bioinformatics; GENOME-WIDE ASSOCIATION; GENETIC RISK-FACTORS; LOCUS; METAANALYSIS; HEALTH; IDENTIFICATION; VARIANTS; ATHEROSCLEROSIS; PREVALENCE; PATHOLOGY;

D O I：

10.3390/genes11111385

中图分类号：

Q3 [遗传学];

学科分类号：

071007 ; 090102 ;

摘要：

Recent studies supported a clinical association between Parkinson's disease (PD) and periodontitis. Hence, investigating possible interactions between proteins associated to these two conditions is of interest. In this study, we conducted a protein-protein network interaction analysis with recognized genes encoding proteins with variants strongly associated with PD and periodontitis. Genes of interest were collected via the Genome-Wide Association Studies (GWAS) database. Then, we conducted a protein interaction analysis, using the Search Tool for the Retrieval of Interacting Genes/Proteins (STRING) database, with a highest confidence cutoff of 0.9 and sensitivity analysis with confidence cutoff of 0.7. Our protein network casts a comprehensive analysis of potential protein-protein interactions between PD and periodontitis. This analysis may underpin valuable information for new candidate molecular mechanisms between PD and periodontitis and may serve new potential targets for research purposes. These results should be carefully interpreted, giving the limitations of this approach.

引用

页数：15

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