Genetic Factors Associated with Slow Progression of HIV among Perinatally-Infected Indian Children

被引：11

作者：

Chaudhuri, Riya Pal ^{[1
]}

Neogi, Ujjwal ^{[2
]}

Rao, Shwetha D.

Shet, Anita ^{[3
]}

机构：

[1] St Johns Med Coll Hosp, Dept Clin Virol, Bangalore 560034, Karnataka, India

[2] St Johns Med Coll Hosp, Dept Microbiol, Hematol Res Unit, Bangalore 560034, Karnataka, India

[3] St Johns Med Coll Hosp, Dept Pediat, Bangalore 560034, Karnataka, India

来源：

INDIAN PEDIATRICS | 2014年 / 51卷 / 10期

基金：

英国惠康基金;

关键词：

Genetics; Human Immunodeficiency virus; Outcome; Progression; PROGNOSTIC VALUE; CCR5; CCR5-DELTA-32;

D O I：

10.1007/s13312-014-0505-x

中图分类号：

R72 [儿科学];

学科分类号：

100202 ;

摘要：

Objectives: To, study the association between. common AIDS restriction genes, and slow disease progression among perinatally-infected children in India. Methods: ART-naive children were identified and selected host factors including CCR5-Delta 32, SDF1-3'A, CCR5-59029G, HLA-B"27, B*57 were studied using allele-specific PCR-RFLP and SSPGo HLA typing kits. Results: Among 165 children, 10 (6%) long-term non-progressors and 8 (5%) slow progressors were identified. For comparison, 12 children with normal progression of HIV were included. The frequencies of CCR5-Delta 32 deletion, SDF1-3'A and CCR5-59029G did not differ significantly. HLA-B"27 and B*57 were observed only in long-term non-progressors or slow progressors, who also harbored either SDF1-3'A and/or CCR5-59029G. Conclusions: There is an association between host genetic factors and slow disease progression in this population.

引用

页码：801 / 803

页数：3

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