Increased expression of type VI collagen genes in cutis laxa fibroblasts

被引：5

作者：

Hatamochi, A ^{[1
]}

Arakawa, M ^{[1
]}

Mori, K ^{[1
]}

Mori, Y ^{[1
]}

Ueki, H ^{[1
]}

Yoshioka, H ^{[1
]}

机构：

[1] OKAYAMA UNIV, SCH MED,DEPT MOLEC BIOL & BIOCHEM, OKAYAMA 700, JAPAN

来源：

JOURNAL OF DERMATOLOGICAL SCIENCE | 1996年 / 11卷 / 02期

关键词：

cutis laxa; fibroblast; type VI collagen; gene expression;

D O I：

10.1016/0923-1811(95)00425-4

中图分类号：

R75 [皮肤病学与性病学];

学科分类号：

100206 ;

摘要：

Type VI collagen gene expression in cutis laxa was studied by measuring messenger RNA (mRNA) and protein production levels in four fibroblast strains from patients with congenital cutis laxa and comparing them with those in fibroblasts obtained from age-matched healthy subjects. Levels of type YI collagen mRNA were increased in all cutis laxa fibroblast strains and the levels of alpha(1) (VI) and alpha(3) (VI) chain mRNAs increased in parallel. Increases in type VI collagen mRNAs correlated well with production levels of the corresponding proteins, as determined by immunological assay. These results suggest that increased type VI collagen gene expression is one of the characteristics of cutis laxa dermal fibroblasts and that this abnormality may be related to the skin changes in cutis laxa.

引用

页码：97 / 103

页数：7

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