共 43 条
ELR-CXC chemokine antagonism is neuroprotective in a rat model of ischemic stroke
被引:20
作者:

Connell, Barry J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada

Gordon, John R.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Saskatchewan, Dept Med, Div Respirol Crit Care & Sleep Med, Saskatoon, SK S7N 0W0, Canada Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada

Saleh, Tarek M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada
机构:
[1] Univ Prince Edward Isl, Atlantic Vet Coll, Dept Biomed Sci, Charlottetown, PE C1A 4P3, Canada
[2] Univ Saskatchewan, Dept Med, Div Respirol Crit Care & Sleep Med, Saskatoon, SK S7N 0W0, Canada
关键词:
Anti-inflammatory;
Neutrophil;
Stroke;
Reperfusion injury;
Middle cerebral artery occlusion;
CEREBRAL-ARTERY OCCLUSION;
INTESTINAL ISCHEMIA;
REPERFUSION INJURY;
LUNG INJURY;
INFLAMMATORY RESPONSES;
RECEPTORS CXCR1;
BRAIN;
PREVENTION;
REPERTAXIN;
INHIBITOR;
D O I:
10.1016/j.neulet.2015.08.041
中图分类号:
Q189 [神经科学];
学科分类号:
071006 ;
摘要:
Inflammation-related cerebral damage mediated by infiltrating neutrophils following reperfusion plays a role in reperfusion-induced brain damage subsequent to a stroke event. The ELR-CXC family of chemokines are CXCR1 and CXCR2 agonists that are known to drive neutrophil migration and activation. The present study demonstrated the benefit of anti-inflammatory therapy in the treatment of ischemic stroke with the administration of the competitive ELR-CXC chemokine antagonist, CXCL8((3-72))K11R/G31P (G31P). Male Sprague-Dawley rats were anaesthetized, and the middle cerebral artery (MCA) was occluded for 30 min followed by 5.5 h of reperfusion. Pretreatment with G31P resulted in a significant, dose-dependent (approximately 61-72%) decrease in infarct volumes compared to vehicle-treated animals, but neuroprotection was also observed when G31P (0.5 mg/kg) was administered 1 or 3 h following the start of reperfusion. The neuroprotection observed following the administration of this competitive CXCR1/CXCR2 antagonist may present therapeutic opportunities for addressing reperfusion-induced inflammatory damage in patients presenting with transient ischemic episodes. (C) 2015 Elsevier Ireland Ltd. All rights reserved.
引用
收藏
页码:117 / 122
页数:6
相关论文
共 43 条
[1]
Neutrophils do not contribute to infarction, oxidative stress, and NO synthase activity in severe brain ischemia
[J].
Beray-Berthat, V
;
Palmier, B
;
Plotkine, M
;
Margaill, I
.
EXPERIMENTAL NEUROLOGY,
2003, 182 (02)
:446-454

Beray-Berthat, V
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Pharmacol Lab, UPRES, EA 2510, F-75270 Paris 06, France Univ Paris 05, Pharmacol Lab, UPRES, EA 2510, F-75270 Paris 06, France

Palmier, B
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Pharmacol Lab, UPRES, EA 2510, F-75270 Paris 06, France Univ Paris 05, Pharmacol Lab, UPRES, EA 2510, F-75270 Paris 06, France

Plotkine, M
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Paris 05, Pharmacol Lab, UPRES, EA 2510, F-75270 Paris 06, France Univ Paris 05, Pharmacol Lab, UPRES, EA 2510, F-75270 Paris 06, France

论文数: 引用数:
h-index:
机构:
[2]
Noncompetitive allosteric inhibitors of the inflammatory chemokine receptors CXCR1 and CXCR2: Prevention of reperfusion injury
[J].
Bertini, R
;
Allegretti, M
;
Bizzarri, C
;
Moriconi, A
;
Locati, M
;
Zampella, G
;
Cervellera, MN
;
Di Cioccio, V
;
Cesta, MC
;
Galliera, E
;
Martinez, FO
;
Di Bitondo, R
;
Troiani, G
;
Sabbatini, V
;
D'Anniballe, G
;
Anacardio, R
;
Cutrin, JC
;
Cavalieri, B
;
Mainiero, F
;
Strippoli, R
;
Villa, P
;
Di Girolamo, M
;
Martin, F
;
Gentile, M
;
Santoni, A
;
Corda, D
;
Poli, G
;
Mantovani, A
;
Ghezzi, P
;
Colotta, F
.
PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA,
2004, 101 (32)
:11791-11796

Bertini, R
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Allegretti, M
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Bizzarri, C
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Moriconi, A
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Locati, M
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Zampella, G
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Cervellera, MN
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Di Cioccio, V
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Cesta, MC
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Galliera, E
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Martinez, FO
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Di Bitondo, R
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Troiani, G
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Sabbatini, V
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

D'Anniballe, G
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Anacardio, R
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Cutrin, JC
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Cavalieri, B
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Mainiero, F
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Strippoli, R
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Villa, P
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Di Girolamo, M
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Martin, F
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Gentile, M
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Santoni, A
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Corda, D
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Poli, G
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Mantovani, A
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Ghezzi, P
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy

Colotta, F
论文数: 0 引用数: 0
h-index: 0
机构: Dompe, I-67100 Laquila, Italy
[3]
Roles for C-X-C chemokines and C5a in lung injury after hindlimb ischemia-reperfusion
[J].
Bless, NM
;
Warner, RL
;
Padgaonkar, VA
;
Lentsch, AB
;
Czermak, BJ
;
Schmal, H
;
Friedl, HP
;
Ward, PA
.
AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY,
1999, 276 (01)
:L57-L63

Bless, NM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Warner, RL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Padgaonkar, VA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Lentsch, AB
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Czermak, BJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Schmal, H
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Friedl, HP
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA

Ward, PA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Michigan, Sch Med, Dept Pathol, Ann Arbor, MI 48109 USA
[4]
Inhibition of interleukin-8 (CXCL8/IL-8) responses by repertaxin, a new inhibitor of the chemokine receptors CXCR1 and CXCR2
[J].
Casilli, F
;
Bianchini, A
;
Gloaguen, I
;
Biordi, L
;
Alesse, E
;
Festuccia, C
;
Cavalieri, B
;
Strippoli, R
;
Cervellera, MN
;
Di Bitondo, R
;
Ferretti, E
;
Mainiero, F
;
Bizzarri, C
;
Colotta, F
;
Bertini, R
.
BIOCHEMICAL PHARMACOLOGY,
2005, 69 (03)
:385-394

Casilli, F
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Bianchini, A
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Gloaguen, I
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Biordi, L
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Alesse, E
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Festuccia, C
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Cavalieri, B
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Strippoli, R
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Cervellera, MN
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Di Bitondo, R
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Ferretti, E
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Mainiero, F
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Bizzarri, C
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Colotta, F
论文数: 0 引用数: 0
h-index: 0
机构: Dompe SpA, Res Ctr, Laquila, Italy

Bertini, R
论文数: 0 引用数: 0
h-index: 0
机构:
Dompe SpA, Res Ctr, Laquila, Italy Dompe SpA, Res Ctr, Laquila, Italy
[5]
EVIDENCE FOR TUMOR NECROSIS FACTOR-INDUCED PULMONARY MICROVASCULAR INJURY AFTER INTESTINAL ISCHEMIA REPERFUSION INJURY
[J].
CATY, MG
;
GUICE, KS
;
OLDHAM, KT
;
REMICK, DG
;
KUNKEL, SI
.
ANNALS OF SURGERY,
1990, 212 (06)
:694-700

CATY, MG
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN,SCH MED,DEPT SURG,PEDIAT SURG SECT,ANN ARBOR,MI 48104

GUICE, KS
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN,SCH MED,DEPT SURG,PEDIAT SURG SECT,ANN ARBOR,MI 48104

OLDHAM, KT
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN,SCH MED,DEPT SURG,PEDIAT SURG SECT,ANN ARBOR,MI 48104

REMICK, DG
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN,SCH MED,DEPT SURG,PEDIAT SURG SECT,ANN ARBOR,MI 48104

KUNKEL, SI
论文数: 0 引用数: 0
h-index: 0
机构: UNIV MICHIGAN,SCH MED,DEPT SURG,PEDIAT SURG SECT,ANN ARBOR,MI 48104
[6]
A novel rodent model of reperfusion injury following occlusion of the middle cerebral artery
[J].
Connell, Barry J.
;
Saleh, Tarek M.
.
JOURNAL OF NEUROSCIENCE METHODS,
2010, 190 (01)
:28-33

Connell, Barry J.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Prince Edward Isl, Dept Biomed Sci, Atlantic Vet Coll, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl, Dept Biomed Sci, Atlantic Vet Coll, Charlottetown, PE C1A 4P3, Canada

Saleh, Tarek M.
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Prince Edward Isl, Dept Biomed Sci, Atlantic Vet Coll, Charlottetown, PE C1A 4P3, Canada Univ Prince Edward Isl, Dept Biomed Sci, Atlantic Vet Coll, Charlottetown, PE C1A 4P3, Canada
[7]
Cerebral protection in homozygous null ICAM-1 mice after middle cerebral artery occlusion - Role of neutrophil adhesion in the pathogenesis of stroke
[J].
Connolly, ES
;
Winfree, CJ
;
Springer, TA
;
Naka, Y
;
Liao, H
;
Yan, SD
;
Stern, DM
;
Solomon, RA
;
GutierrezRamos, JC
;
Pinsky, DJ
.
JOURNAL OF CLINICAL INVESTIGATION,
1996, 97 (01)
:209-216

Connolly, ES
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

Winfree, CJ
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

Springer, TA
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

Naka, Y
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

Liao, H
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

Yan, SD
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

Stern, DM
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

Solomon, RA
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

GutierrezRamos, JC
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA

Pinsky, DJ
论文数: 0 引用数: 0
h-index: 0
机构: COLUMBIA UNIV COLL PHYS & SURG, DEPT NEUROSURG, NEW YORK, NY 10032 USA
[8]
Identification of two rat genes orthologous to the human interleukin-8 receptors
[J].
Dunstan, CAN
;
Salafranca, MN
;
Adhikari, S
;
Xia, YY
;
Feng, LL
;
Harrison, JK
.
JOURNAL OF BIOLOGICAL CHEMISTRY,
1996, 271 (51)
:32770-32776

Dunstan, CAN
论文数: 0 引用数: 0
h-index: 0
机构: UNIV FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, GAINESVILLE, FL 32610 USA

Salafranca, MN
论文数: 0 引用数: 0
h-index: 0
机构: UNIV FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, GAINESVILLE, FL 32610 USA

Adhikari, S
论文数: 0 引用数: 0
h-index: 0
机构: UNIV FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, GAINESVILLE, FL 32610 USA

Xia, YY
论文数: 0 引用数: 0
h-index: 0
机构: UNIV FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, GAINESVILLE, FL 32610 USA

Feng, LL
论文数: 0 引用数: 0
h-index: 0
机构: UNIV FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, GAINESVILLE, FL 32610 USA

Harrison, JK
论文数: 0 引用数: 0
h-index: 0
机构: UNIV FLORIDA, COLL MED, DEPT PHARMACOL & THERAPEUT, GAINESVILLE, FL 32610 USA
[9]
Inflammatory leukocyte infiltration in focal cerebral ischemia:: Unrelated to infarct size
[J].
Fassbender, K
;
Ragoschke, A
;
Kühl, S
;
Szabo, K
;
Fatar, M
;
Back, W
;
Bertsch, T
;
Kreisel, S
;
Hennerici, M
.
CEREBROVASCULAR DISEASES,
2002, 13 (03)
:198-203

论文数: 引用数:
h-index:
机构:

Ragoschke, A
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Univ Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany

Kühl, S
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Univ Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany

Szabo, K
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Univ Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany

Fatar, M
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Univ Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany

Back, W
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Univ Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany

Bertsch, T
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Univ Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany

Kreisel, S
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Univ Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany

Hennerici, M
论文数: 0 引用数: 0
h-index: 0
机构: Heidelberg Univ, Univ Clin Mannheim, Dept Neurol, D-68135 Mannheim, Germany
[10]
Chemokines in ischemia and reperfusion
[J].
Frangogiannis, Nikolaos G.
.
THROMBOSIS AND HAEMOSTASIS,
2007, 97 (05)
:738-747

Frangogiannis, Nikolaos G.
论文数: 0 引用数: 0
h-index: 0
机构:
Baylor Coll Med, Cardiovasc Sci Sect, Dept Med, Houston, TX 77030 USA Baylor Coll Med, Cardiovasc Sci Sect, Dept Med, Houston, TX 77030 USA