Isoxazoline containing natural products as anticancer agents: A review

被引：257

作者：

Kaur, Kamalneet ^{[1
]}

Kumar, Vinod ^{[1
]}

Sharma, Anil Kumar ^{[2
]}

Gupta, Girish Kumar ^{[3
]}

机构：

[1] Maharishi Markandeshwar Univ, Dept Chem, Mullana 133207, Ambala, India

[2] Maharishi Markandeshwar Univ, Dept Biotechnol, Mullana 133207, Ambala, India

[3] Maharishi Markandeshwar Univ, Dept Pharmaceut Chem, Mullana 133207, Ambala, India

来源：

EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2014年 / 77卷

关键词：

Isoxazolines; Anticancer; Cytotoxic; Stereochemistry; Natural products; SPONGE PSAMMAPLYSILLA-PURPUREA; DIBROMOTYROSINE-DERIVED METABOLITE; BIOACTIVE BROMINATED METABOLITES; MARINE SPONGE; BROMOTYROSINE ALKALOIDS; APLYSINA-GERARDOGREENI; BIOLOGICAL EVALUATION; PSEUDOCERATINA-ARABICA; SECONDARY METABOLITE; STRUCTURAL REVISION;

D O I：

10.1016/j.ejmech.2014.02.063

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Isoxazolines are an important class of nitrogen and oxygen containing heterocycles that belong to the azoles family which have gained much importance in the field of medicinal chemistry as the anticancer agents. Moreover, natural products are always expectedly regarded as an important hoard of a large number of potential chemotherapeutic candidates. Therefore, this review mainly focuses on the existence of isoxazoline derivatives in natural sources, their isolation and uses there of as anticancer agents besides highlighting the synthetic pathways to achieve these compounds. Structural activity relationship and the influence of stereochemical aspects on anticancer activity of such compounds have also been discussed. It covers the literature upto 2014 and would certainly provide a great insight to scientific community to accelerate further research for the development of some novel anticancer drugs. (C) 2014 Elsevier Masson SAS. All rights reserved.

引用

页码：121 / 133

页数：13

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