Nanoscale Fluorescent Metal-Organic Framework@Microporous Organic Polymer Composites for Enhanced Intracellular Uptake and Bioimaging

被引：52

作者：

Wang, Lei ^{[1
]}

Wang, Weiqi ^{[1
,2
]}

Zheng, Xiaohua ^{[1
,2
]}

Li, Zhensheng ^{[1
]}

Xie, Zhigang ^{[1
]}

机构：

[1] Chinese Acad Sci, Changchun Inst Appl Chem, State Key Lab Polymer Phys & Chem, Changchun 130022, Peoples R China

[2] Chinese Acad Sci, Beijing 100049, Peoples R China

来源：

CHEMISTRY-A EUROPEAN JOURNAL | 2017年 / 23卷 / 06期

基金：

中国国家自然科学基金;

关键词：

bioimaging; cellular uptake; metal-organic frameworks; microporous organic polymers; FOLIC-ACID; COORDINATION POLYMERS; HIGHLY EFFICIENT; FABRICATION; FUNCTIONALIZATION; NANOPARTICLES; THERAPY; RELEASE; CANCER; CO2;

D O I：

10.1002/chem.201604416

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Polymer-modified metal-organic frameworks combine the advantages of both soft polymers and crystalline metal-organic frameworks (MOFs). It is a big challenge to develop simple methods for surface modification of MOFs. In this work, MOF@microporous organic polymer (MOP) hybrid nanoparticles (UNP) have been synthesized by epitaxial growth of luminescent boron-dipyrromethene (BODIPYs)-imine MOPs on the surface of UiO-MOF seeds, which exhibit low cytotoxicity, smaller size distribution, well-retained pore integrity, and available functional sites. After folic acid grafting, the enhanced intracellular uptake and bioimaging was validated.

引用

收藏

页码：1379 / 1385

页数：7

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