Chiral Amide Directed Assembly of a Diastereo- and Enantiopure Supramolecular Host and its Application to Enantioselective Catalysis of Neutral Substrates

被引：191

作者：

Zhao, Chen

Sun, Qing-Fu

Hart-Cooper, William M.

Dipasquale, Antonio G.

Toste, F. Dean ^{[1
]}

Bergman, Robert G.

Raymond, Kenneth N.

机构：

[1] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Chem Sci, Berkeley, CA 94720 USA

来源：

JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 50期

关键词：

STABILIZATION; ENCAPSULATION; RECOGNITION; CHEMISTRY; CAGE;

D O I：

10.1021/ja411631v

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The synthesis of a novel supramolecular tetrahedral assembly of K12Ga4L6 stoichiometry is reported. The newly designed chiral ligand exhibits high diastereoselective control during cluster formation, leading exclusively to a single diastereomer of the desired host. This new assembly also exhibits high stability toward oxidation or a low pH environment and is a more robust and efficient catalyst for asymmetric organic transformations of neutral substrates.

引用

页码：18802 / 18805

页数：4