Chiral Amide Directed Assembly of a Diastereo- and Enantiopure Supramolecular Host and its Application to Enantioselective Catalysis of Neutral Substrates

被引：193
作者：
Zhao, Chen
Sun, Qing-Fu
Hart-Cooper, William M.
Dipasquale, Antonio G.
Toste, F. Dean [1 ]
Bergman, Robert G.
Raymond, Kenneth N.
机构：
[1] Univ Calif Berkeley, Lawrence Berkeley Natl Lab, Div Chem Sci, Berkeley, CA 94720 USA
来源：
JOURNAL OF THE AMERICAN CHEMICAL SOCIETY | 2013年 / 135卷 / 50期
关键词：
STABILIZATION; ENCAPSULATION; RECOGNITION; CHEMISTRY; CAGE;
D O I：
10.1021/ja411631v
中图分类号：
O6 [化学];
学科分类号：
0703 ;
摘要：
The synthesis of a novel supramolecular tetrahedral assembly of K12Ga4L6 stoichiometry is reported. The newly designed chiral ligand exhibits high diastereoselective control during cluster formation, leading exclusively to a single diastereomer of the desired host. This new assembly also exhibits high stability toward oxidation or a low pH environment and is a more robust and efficient catalyst for asymmetric organic transformations of neutral substrates.
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收藏
页码：18802 / 18805
页数：4
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