New evidence of red blood cell rheological disorders in β-thalassaemia minor

被引:0
作者
Pérez, S
Milani, A
Acosta, L
Rasia, RJ
机构
[1] Univ Nacl Rosario, Dept Ciencias Bioquim & Farmaceut, Dept Bioquim Clin, Hematol Serv, RA-2000 Rosario, Argentina
[2] Univ Nacl Rosario, Fac Ciencias Bioquim & Farmaceut, Area Fis, RA-2000 Rosario, Santa Fe, Argentina
[3] Univ Nacl Rosario, CONICET, Grp Bioopt, Inst Fis Rosario, RA-2000 Rosario, Santa Fe, Argentina
关键词
beta-thalassaemia minor; erythrocyte rheology; creep and recovery curves;
D O I
暂无
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
Haemorheological parameters, such as red blood cell deformability, membrane elastic modulus and membrane surface viscosity in twenty one thalassaemia heterozygous patients (14)beta(0)/beta and 7 beta(+)/beta) were compared with normal individuals (n = 15). Parameters were measured applying a laser diffractometric method (ektacytometry). Thalassaemia erythrocytes showed statistically significant lower deformability and higher elastic modulus. Surface viscosity showed no significant differences in thalassaemia. Creep and recovery curves were registered by diffractometry. The normal recovery curve was fitted by a first order exponential decay function, expressing the fitting degree by the chi(2) coefficient. The shape of the recovery curve in beta-thalassaeniia patients (beta(o)/beta or beta(+)/beta) was significantly different from the control group. The possible mechanism of red blood cells abnormal rheological behaviour in beta-thalassaemia minor could be explained by a surface charge reduction. Our results enable us to conclude that the shape of the recovery curve (chi(2) coefficient) could be considered as a marker that might be useful in beta-thalassaemia diagnosis.
引用
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页码:89 / 96
页数:8
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