Mitochondria and the Brain: Bioenergetics and Beyond

被引：43

作者：

Belenguer, Pascale ^{[1
]}

Duarte, Joao M. N. ^{[2
,3
]}

Schuck, Patricia F. ^{[4
,5
]}

Ferreira, Gustavo C. ^{[6
]}

机构：

[1] Toulouse Univ, Ctr Integrat Biol CBI, Res Ctr Anim Cognit CRCA, CNRS,UPS, Toulouse, France

[2] Lund Univ, Fac Med, Dept Expt Med Sci, Lund, Sweden

[3] Lund Univ, Wallenberg Ctr Mol Med, Lund, Sweden

[4] Pontificia Univ Catolica Rio Grande do Sul, Lab Inborn Errors Metab, Porto Alegre, RS, Brazil

[5] Pontificia Univ Catolica Rio Grande do Sul, Grad Program Cellular & Mol Biol, Porto Alegre, RS, Brazil

[6] Univ Fed Rio de Janeiro, Lab Neuroenerget & Inborn Errors Metab, Inst Med Biochem Leopoldo de Meis, Ave Carlos Chagas Filho 373,Bloco E,Sala 38, BR-21941902 Rio De Janeiro, RJ, Brazil

来源：

NEUROTOXICITY RESEARCH | 2019年 / 36卷 / 02期

基金：

瑞典研究理事会;

关键词：

Mitochondria; Neurogenesis; MRS; Brain metabolism; MAGNETIC-RESONANCE-SPECTROSCOPY; DOMINANT OPTIC ATROPHY; MILD COGNITIVE IMPAIRMENT; TRANSGENIC MOUSE MODELS; DYNAMIN-RELATED PROTEIN; PROGRAMMED CELL-DEATH; COMPLEX-I DEFICIENCY; ALZHEIMERS-DISEASE; ENERGY-METABOLISM; HUNTINGTONS-DISEASE;

D O I：

10.1007/s12640-019-00061-7

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

The view of mitochondria acting solely as a powerhouse of the cell is no longer accurate. Besides cell bioenergetics, primary targets of mitochondrial studies include their interplay with essential processes within the cell, including redox and calcium homeostasis, and apoptosis. Recent studies evidence the dynamic behavior of mitochondria, continuously moving, fusing, and dividing, and the interaction of these events with cellular degeneration and plasticity in neural cells. Our review summarizes novel data and technologies that are developed and applied to the identification and clarification of the mitochondrial role in neural plasticity using both cultured cells and in vivo approaches. The complete understanding and modulation of such mechanisms may represent a novel and promising therapeutic approach for treatment of diseases affecting central and peripheral nervous system.

引用

页码：219 / 238

页数：20

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