Association between AXIN1 gene polymorphisms and epithelial ovarian cancer in Chinese population

被引：3
|
作者：
Zhang, Yan [1 ,2 ]
Wang, Yanyun [2 ]
Huang, Xingming [1 ,2 ]
Li, Qin [2 ,3 ]
Li, Kai [2 ,4 ]
You, Di [2 ,5 ]
Song, Yaping [2 ]
Su, Min [2 ]
Zhou, Bin [2 ]
Wang, Wei [1 ]
机构：
[1] Sichuan Univ, West China Univ Hosp 2, Dept Pathol, Chengdu 610041, Sichuan, Peoples R China
[2] Sichuan Univ, West China Univ Hosp 2, Key Lab Birth Defects & Related Dis Women & Child, Ctr Translat Med,Lab Mol Translat Med,Minist Educ, Chengdu 610041, Sichuan, Peoples R China
[3] Sichuan Univ, West China Sch Preclin & Forens Med, Dept Immunol, Chengdu 610041, Sichuan, Peoples R China
[4] Sichuan Univ, West China Hosp, Dept Cardiol, Chengdu 610041, Sichuan, Peoples R China
[5] Sichuan Univ, West China Univ Hosp 2, Dept Obstet & Gynecol, Chengdu 610041, Sichuan, Peoples R China
来源：
BIOMARKERS IN MEDICINE | 2019年 / 13卷 / 06期
基金：
中国国家自然科学基金;
关键词：
AXIN1; gene; epithelial ovarian cancer; morphisms; PCR-RFLP; single nucleotide polymorphisms; Wnt/beta-catenin signaling pathway; WNT/BETA-CATENIN PATHWAY; BETA-CATENIN; PROGNOSTIC-FACTORS; MUTATIONS; CELL; EXPRESSION; SUSCEPTIBILITY; CARCINOMA; VARIANTS; ORIGIN;
D O I：
10.2217/bmm-2018-0306
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
Aim: The study was aimed to explore the association between AXIN1 gene polymorphism and epithelial ovarian cancer (EOC) susceptibility as well as prognosis. Methods: A total of 165 EOC cases and 327 healthy controls were recruited to participate in this study. In total three tag SNPs in AXIN1 gene were genotyped using PCR-restriction fragment length polymorphism. Results: Significantly increased EOC risk was found associated with the A/C heterozygous genotype of rs12921862, the C allele and C/T genotype in the rs1805105 and the T/T genotype of rs370681. Meanwhile, Kaplan-Meier survival curves showed that patients with rs12921862 C/C genotype improved overall survival in the EOC group. Conclusion: Our results suggest that the AXIN1 gene may be related to susceptibility and overall survival in EOC.
引用
收藏
页码：445 / 455
页数：11
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