Prognostic Impact of Lymphatic Invasion in Patients With Node-Negative Gastric Cancer

被引:32
作者
Ichikawa, Daisuke [1 ]
Kubota, Takeshi [1 ]
Kikuchi, Shojiro [1 ]
Fujiwara, Hitoshi [1 ]
Konishi, Hirotaka [1 ]
Tsujiura, Masahiro [1 ]
Ikoma, Hisashi [1 ]
Nakanishi, Masayoshi [1 ]
Okamoto, Kazuma [1 ]
Sakakura, Chohei [1 ]
Ochiai, Toshiya [1 ]
Kokuba, Yukihito [1 ]
Otsuji, Eigo [1 ]
机构
[1] Kyoto Prefectural Univ Med, Dept Surg, Div Digest Surg, Kamigyo Ku, Kyoto 6028566, Japan
关键词
lymphatic vessel; survival; prognostic factors; invasion; EXPRESSION; METASTASIS; SURVIVAL;
D O I
10.1002/jso.21311
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Background and Objectives:This study investigated the prognostic impact of lymphatic invasion on the outcome of patients with node-negative gastric cancer. Methods: A total of 828 patients with node-negative gastric cancer who underwent curative gastretomy were reviewed retrospectively. The clinicopathological features and prognoses of patients with lymphatic invasion were compared to those of patients without such invasion. Results: The total rate of lymphatic invasion was 18.2% in node-negative gastric cancers, with a significant difference between early gastric cancers (9.8%) and advanced gastric cancers (49.2%). The presence of lymphatic invasion correlated significantly with tumor location, size and depth of tumor(P < 0.01). Lymphatic invasion was significantly associated with a poorer overall survival in node-negative gastric cancer patients on univariate analysis (P < 0.001) as well as multivariate analysis (P < 0.01). Conclusions: Lymphatic invasion provides additional useful information that could be applied to identify patients at high risk for recurrence who might be candidates for adjuvant therapies in patients with node-negative gastric cancers. J. surg. Oncol. 2009:100:111-114. (C) 2009 Wiley-Liss, Inc.
引用
收藏
页码:111 / 114
页数:4
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