Sustained and full fetal hemoglobin production after failure of bone marrow transplant in a patient homozygous for beta 0-thalassemia: A clinical remission despite genetic disease and transplant rejection

被引：11

作者：

Paciaroni, Katia ^{[1
]}

Gallucci, Cristiano ^{[1
]}

De Angelis, Giola ^{[1
]}

Alfieri, Cecilia ^{[1
]}

Roveda, Andrea ^{[1
]}

Lucarelli, Guido ^{[1
]}

机构：

[1] Policlin Tor Vergata, Mediterranean Inst Hematol, Int Ctr Transplantat Thalassemia & Sickle Cell An, I-00152 Rome, Italy

来源：

AMERICAN JOURNAL OF HEMATOLOGY | 2009年 / 84卷 / 06期

关键词：

THALASSEMIA;

D O I：

10.1002/ajh.21392

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

An adult patient affected by beta(o)-thalassemia major underwent allogeneic bone marrow transplant (BMT) from a matched related donor. Forty days after transplant, allogeneic engraftment failure and autologous beta(o)-thalassemic bone marrow recovery were documented. Red blood cell transfusions were required until 118 days post-transplant. Thereafter, the haemoglobin (Hb) levels stabilized over 11.8 gr/dl throughout the ongoing 34-month follow-up, abolishing the need for transfusion support. The Hb electrophoresis showed 100% Hb Fetal (HbF). This unexplained case suggests full HbF production may occur in an adult patient with beta(o)-thalassemia major.

引用

页码：372 / 373

页数：2

共 8 条

[1] Regulation of human fetal hemoglobin: new players, new complexities [J].