The effect of one-year cross-sex hormonal treatment on bone metabolism and serum insulin-like growth factor-1 in transsexuals

被引:84
作者
vanKesteren, P
Lips, P
Deville, W
PoppSnijders, C
Asscheman, H
Megens, J
Gooren, L
机构
[1] FREE UNIV AMSTERDAM HOSP, DEPT ENDOCRINOL, 1007 MB AMSTERDAM, NETHERLANDS
[2] FREE UNIV AMSTERDAM HOSP, DEPT BIOSTAT, 1007 MB AMSTERDAM, NETHERLANDS
关键词
D O I
10.1210/jc.81.6.2227
中图分类号
R5 [内科学];
学科分类号
1002 ; 100201 ;
摘要
The effects of treatment with estrogens and antiandrogens in male to female (M-->F) transsexuals and androgens in female to male (F-->M) transsexuals on their respective bone metabolism, bone mineral density (BMD), serum insulin-like growth factor I(IGF-I) and IGF-binding protein-3 (IGFBP-3) levels were investigated. BMD and variables of br,ne turnover in serum were measured at baseline and after 3 months (except for BMD) and 1 yr of treatment in 56 M-->F and 35 F-->M transsexuals. Serum IGF-I, IGFBP-3, and propeptide of type I procollagen (P1CP) were measured at baseline and after 1 yr of treatment in 10 M-->F and 10 F-->M transsexuals. In M-->F, BMD increased significantly. Bone turnover decreased, as shown by a significant decline in levels of osteocalcin, alkaline phosphatase, P1CP, and fasting urinary calcium/creatinine and hydroxyproline/creatinine ratios. Serum IGF-I levels decreased significantly without significant changes in IGFBP-3 levels. In F-->M, BMD did not change. Bone formation increased, as suggested by an increase in alkaline phosphatase and a borderline increase in P1CP values. IGF-I levels increased significantly, whereas no significant changes were seen in IGFBP-3 levels. We conclude that in males, estrogens (in combination with antiandrogens) decrease bone turnover, with a subsequent increase in BMD and a decrease in serum IGF-I. In females, testosterone administration increases bone formation, but this is not reflected in an increased BMD, whereas serum IGF-I increases.
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页码:2227 / 2232
页数:6
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