Palaeo-Eskimo genetic ancestry and the peopling of Chukotka and North America

被引：98

作者：

Flegontov, Pavel ^{[1
,2
,3
]}

Altinisik, N. Ezgi ^{[1
,26
]}

Changmai, Piya ^{[1
,26
]}

Rohland, Nadin ^{[4
]}

Mallick, Swapan ^{[4
,5
,6
]}

Adamski, Nicole ^{[4
,5
]}

Bolnick, Deborah A. ^{[7
,8
]}

Broomandkhoshbacht, Nasreen ^{[4
,5
]}

Candilio, Francesca ^{[9
,10
]}

Culleton, Brendan J. ^{[11
]}

Flegontova, Olga ^{[2
]}

Friesen, T. Max ^{[12
]}

Jeong, Choongwon ^{[13
]}

Harper, Thomas K. ^{[14
]}

Keating, Denise ^{[9
]}

Kennett, Douglas J. ^{[14
]}

Kim, Alexander M. ^{[4
,15
]}

Lamnidis, Thiseas C. ^{[14
]}

Lawson, Ann Marie ^{[4
]}

Olalde, Inigo ^{[4
]}

Oppenheimer, Jonas ^{[4
]}

Potter, Ben A. ^{[16
]}

Raff, Jennifer ^{[17
]}

Sattler, Robert A. ^{[18
]}

Skoglund, Pontus ^{[19
]}

Stewardson, Kristin ^{[4
,5
]}

Vajda, Edward J. ^{[20
]}

Vasilyev, Sergey ^{[21
]}

Veselovskaya, Elizaveta ^{[21
]}

Hayes, M. Geoffrey ^{[22
,23
,24
]}

O'Rourke, Dennis H. ^{[17
]}

Krause, Johannes

Pinhasi, Ron ^{[25
]}

Reich, David ^{[4
,5
,6
]}

Schiffels, Stephan ^{[13
]}

机构：

[1] Univ Ostrava, Dept Biol & Ecol, Fac Sci, Ostrava, Czech Republic

[2] Czech Acad Sci, Inst Parasitol, Ctr Biol, Ceske Budejovice, Czech Republic

[3] Russian Acad Sci, AA Kharkevich Inst Informat Transmiss Problems, Moscow, Russia

[4] Harvard Med Sch, Dept Genet, Boston, MA USA

[5] Harvard Med Sch, Howard Hughes Med Inst, Boston, MA USA

[6] Broad Inst MIT & Harvard, Cambridge, MA USA

[7] Univ Connecticut, Dept Anthropol, Storrs, CT USA

[8] Univ Connecticut, Inst Syst Genom, Storrs, CT USA

[9] Univ Coll Dublin, Sch Archaeol, Dublin, Ireland

[10] Soprintendenza Archeol Belle Arti & Paesaggio Cit, Cagliari, Italy

[11] Penn State Univ, Inst Energy & Environm, University Pk, PA 16802 USA

[12] Univ Toronto, Dept Anthropol, Toronto, ON, Canada

[13] Univ Toronto, Dept Anthropol, Toronto, ON, Canada

[14] Penn State Univ, Dept Anthropol, University Pk, PA 16802 USA

[15] Harvard Univ, Dept Anthropol, Cambridge, MA 02138 USA

[16] Univ Alaska Fairbanks, Dept Anthropol, Fairbanks, AK USA

[17] Univ Kansas, Dept Anthropol, Lawrence, KS 66045 USA

[18] Tanana Chiefs Conf, Fairbanks, AK USA

[19] Francis Crick Inst, London, England

[20] Western Washington Univ, Dept Modern & Class Languages, Bellingham, WA 98225 USA

[21] Russian Acad Sci, Inst Ethnol & Anthropol, Moscow, Russia

[22] Northwestern Univ, Dept Med, Feinberg Sch Med, Chicago, IL 60611 USA

[23] Northwestern Univ, Dept Anthropol, Chicago, IL 60611 USA

[24] Northwestern Univ, Feinberg Sch Med, Ctr Genet Med, Chicago, IL 60611 USA

[25] Univ Vienna, Dept Anthropol, Vienna, Austria

[26] Univ Calif Santa Barbara, Dept Anthropol, Santa Barbara, CA 93106 USA

来源：

NATURE | 2019年 / 570卷 / 7760期

基金：

英国医学研究理事会; 加拿大自然科学与工程研究理事会; 美国国家科学基金会; 英国惠康基金;

关键词：

GENOME SEQUENCE; POPULATION; ADMIXTURE; DIVERSITY; MIGRATION;

D O I：

10.1038/s41586-019-1251-y

中图分类号：

O [数理科学和化学]; P [天文学、地球科学]; Q [生物科学]; N [自然科学总论];

学科分类号：

07 ; 0710 ; 09 ;

摘要：

Much of the American Arctic was first settled 5,000 years ago, by groups of people known as Palaeo-Eskimos. They were subsequently joined and largely displaced around 1,000 years ago by ancestors of the present-day Inuit and Yup'ik(1-3). The genetic relationship between Palaeo-Eskimos and Native American, Inuit, Yup'ik and Aleut populations remains uncertain(4-6). Here we present genomic data for 48 ancient individuals from Chukotka, East Siberia, the Aleutian Islands, Alaska, and the Canadian Arctic. We co-analyse these data with data from present-day Alaskan Inupiat and West Siberian populations and published genomes. Using methods based on rare-allele and haplotype sharing, as well as established techniques(4,7-9), we show that Palaeo-Eskimo-related ancestry is ubiquitous among people who speak Na-Dene and Eskimo-Aleut languages. We develop a comprehensive model for the Holocene peopling events of Chukotka and North America, and show that Na-Dene-speaking peoples, people of the Aleutian Islands, and Yup'ik and Inuit across the Arctic region all share ancestry from a single Palaeo-Eskimo-related Siberian source.

引用

页码：236 / +

页数：18

共 43 条

[1] Fast model-based estimation of ancestry in unrelated individuals [J].

Alexander, David H. ;

Novembre, John ;

Lange, Kenneth .

GENOME RESEARCH, 2009, 19 (09) :1655-1664

[2] Advancing the ethics of paleogenomics [J].

Bardill, Jessica ;

Bader, Alyssa C. ;

Garrison, Nanibaa' A. ;

Bolnick, Deborah A. ;

Raff, Jennifer A. ;

Walker, Alexa ;

Malhi, Ripan S. .

SCIENCE, 2018, 360 (6387) :384-385

[3] Complete mitochondrial genome sequence of a Middle Pleistocene cave bear reconstructed from ultrashort DNA fragments [J].

Dabney, Jesse ;

Knapp, Michael ;

Glocke, Isabelle ;

Gansauge, Marie-Theres ;

Weihmann, Antje ;

Nickel, Birgit ;

Valdiosera, Cristina ;

Garcia, Nuria ;

Paeaebo, Svante ;

Arsuaga, Juan-Luis ;

Meyer, Matthias .

PROCEEDINGS OF THE NATIONAL ACADEMY OF SCIENCES OF THE UNITED STATES OF AMERICA, 2013, 110 (39) :15758-15763

[4] Cross-cultural estimation of the human generation interval for use in genetics-based population divergence studies [J].

Fenner, JN .

AMERICAN JOURNAL OF PHYSICAL ANTHROPOLOGY, 2005, 128 (02) :415-423

[5] Genomic study of the Ket: a Paleo-Eskimo-related ethnic group with significant ancient North Eurasian ancestry [J].

Flegontov, Pavel ;

Changmai, Piya ;

Zidkova, Anastassiya ;

Logacheva, Maria D. ;

Altinisik, N. Ezgi ;

Flegontova, Olga ;

Gelfand, Mikhail S. ;

Gerasimov, Evgeny S. ;

Khrameeva, Ekaterina E. ;

Konovalova, Olga P. ;

Neretina, Tatiana ;

Nikolsky, Yuri V. ;

Starostin, George ;

Stepanova, Vita V. ;

Travinsky, Igor V. ;

Triska, Martin ;

Triska, Petr ;

Tatarinova, Tatiana V. .

SCIENTIFIC REPORTS, 2016, 6

[6] On the Naming of Arctic Archaeological Traditions: The Case for Paleo-Inuit [J].

Friesen, T. Max .

ARCTIC, 2015, 68 (03) :III-IV

[7]

Friesen T.Max., 2016, The Oxford Handbook of the Prehistoric Arctic, P673

[8] Contemporaneity of Dorset and Thule cultures in the North American Arctic: New radiocarbon dates from Victoria Island, Nunavut [J].

Friesen, TM .

CURRENT ANTHROPOLOGY, 2004, 45 (05) :685-691

[9] An early modern human from Romania with a recent Neanderthal ancestor [J].

Fu, Qiaomei ;

Hajdinjak, Mateja ;

Moldovan, Oana Teodora ;

Constantin, Silviu ;

Mallick, Swapan ;

Skoglund, Pontus ;

Patterson, Nick ;

Rohland, Nadin ;

Lazaridis, Iosif ;

Nickel, Birgit ;

Viola, Bence ;

Pruefer, Kay ;

Meyer, Matthias ;

Kelso, Janet ;

Reich, David ;

Paeaebo, Svante .

NATURE, 2015, 524 (7564) :216-+

[10] Massive migration from the steppe was a source for Indo-European languages in Europe [J].

Haak, Wolfgang ;

Lazaridis, Iosif ;

Patterson, Nick ;

Rohland, Nadin ;

Mallick, Swapan ;

Llamas, Bastien ;

Brandt, Guido ;

Nordenfelt, Susanne ;

Harney, Eadaoin ;

Stewardson, Kristin ;

Fu, Qiaomei ;

Mittnik, Alissa ;

Banffy, Eszter ;

Economou, Christos ;

Francken, Michael ;

Friederich, Susanne ;

Pena, Rafael Garrido ;

Hallgren, Fredrik ;

Khartanovich, Valery ;

Khokhlov, Aleksandr ;

Kunst, Michael ;

Kuznetsov, Pavel ;

Meller, Harald ;

Mochalov, Oleg ;

Moiseyev, Vayacheslav ;

Nicklisch, Nicole ;

Pichler, Sandra L. ;

Risch, Roberto ;

Rojo Guerra, Manuel A. ;

Roth, Christina ;

Szecsenyi-Nagy, Anna ;

Wahl, Joachim ;

Meyer, Matthias ;

Krause, Johannes ;

Brown, Dorcas ;

Anthony, David ;

Cooper, Alan ;

Alt, Kurt Werner ;

Reich, David .

NATURE, 2015, 522 (7555) :207-+

← 1 2 3 4 5 →