Thermal ablation of tumours: biological mechanisms and advances in therapy

被引:1590
作者
Chu, Katrina F. [1 ]
Dupuy, Damian E.
机构
[1] Brown Univ, Warren Alpert Med Sch, Dept Diagnost Imaging, Providence, RI 02903 USA
关键词
COMBINED RADIOFREQUENCY ABLATION; HEAT-SHOCK PROTEINS; MONKEY MACAQUE PROSTATE; LIPOSOMAL DOXORUBICIN; IRREVERSIBLE ELECTROPORATION; HEPATOCELLULAR-CARCINOMA; DENDRITIC CELLS; COMBINATION THERAPY; ANTITUMOR IMMUNITY; MICROWAVE ABLATION;
D O I
10.1038/nrc3672
中图分类号
R73 [肿瘤学];
学科分类号
100214 ;
摘要
Minimally invasive thermal ablation of tumours has become common since the advent of modern imaging. From the ablation of small, unresectable tumours to experimental therapies, percutaneous radiofrequency ablation, microwave ablation, cryoablation and irreversible electroporation have an increasing role in the treatment of solid neoplasms. This Opinion article examines the mechanisms of tumour cell death that are induced by the most common thermoablative techniques and discusses the rapidly developing areas of research in the field, including combinatorial ablation and immunotherapy, synergy with conventional chemotherapy and radiation, and the development of a new ablation modality in irreversible electroporation.
引用
收藏
页码:199 / 208
页数:10
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