Montreal Cognitive Assessment Memory Index Score (MoCA-MIS) as a Predictor of Conversion from Mild Cognitive Impairment to Alzheimer's Disease

被引:197
作者
Julayanont, Parunyou [1 ,2 ]
Brousseau, Melanie [1 ]
Chertkow, Howard [3 ,4 ,5 ,6 ]
Phillips, Natalie [3 ,7 ]
Nasreddine, Ziad S. [1 ,4 ,5 ]
机构
[1] Ctr Diag & Res Alzheimers Dis, Greenfield Pk, PQ, Canada
[2] Chulalongkorn Univ, Fac Med, Dept Internal Med, Bangkok 10330, Thailand
[3] Montreal Gen Hosp, Bloomfield Ctr Res Aging, Lady Davis Inst, Montreal, PQ H3G 1A4, Canada
[4] McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Dept Clin Neurosci, Montreal, PQ, Canada
[5] McGill Univ, Sir Mortimer B Davis Jewish Gen Hosp, Div Geriatr Med, Montreal, PQ, Canada
[6] Univ Montreal, Univ Inst Geriatr, Res Ctr, Montreal, PQ, Canada
[7] Concordia Univ, Dept Psychol, Ctr Res Human Dev, Montreal, PQ H3G 1M8, Canada
关键词
Montreal Cognitive Assessment; mild cognitive impairment; Alzheimer; Memory Index Score; DEMENTIA; DIAGNOSIS; HIPPOCAMPAL; BIOMARKERS; DECLINE; MRI;
D O I
10.1111/jgs.12742
中图分类号
R592 [老年病学]; C [社会科学总论];
学科分类号
03 ; 0303 ; 100203 ;
摘要
Objectives To assess the usefulness of the Montreal Cognitive Assessment (MoCA) total score (MoCA-TS) and Memory Index Score (MoCA-MIS) in predicting conversion to Alzheimer's disease (AD) in individuals with mild cognitive impairment (MCI). Design Retrospective chart review. Setting Community-based memory clinic. Participants Individuals meeting Petersen's MCI criteria (N=165). Measurements Baseline MoCA scores at MCI diagnosis were collected from charts of eligible individuals with MCI, and MoCA-TS, MoCA-MIS, and a cognitive domain index score were calculated to assess their prognostic value in predicting conversion to AD. Results One hundred fourteen participants progressed to AD (MCI-AD), and 51 did not (nonconverters; MCI-NC); 90.5% of participants with MCI with a MoCA-TS less than 20/30 and a MoCA-MIS less than 7/15 at baseline converted to AD within the average follow-up period of 18months, compared with 52.7% of participants with MCI above the cutoffs on both scores. Individuals with multiple-domain amnestic MCI had the highest AD conversion rates (73.9%). Conclusion Identifying individuals with MCI at high risk of conversion to AD is important clinically and for selecting appropriate subjects for therapeutic trials. Individuals with MCI with a low MoCA-TS and a low newly devised memory index score (MoCA-MIS) are at greater risk of short-term conversion to AD.
引用
收藏
页码:679 / 684
页数:6
相关论文
共 50 条
[41]   Prediction of conversion from mild cognitive impairment to Alzheimer's disease dementia based upon biomarkers and neuropsychological test performance [J].
Ewers, Michael ;
Walsh, Cathal ;
Trojanowski, John Q. ;
Shaw, Leslie M. ;
Petersen, Ronald C. ;
Jack, Clifford R., Jr. ;
Feldman, Howard H. ;
Bokde, Arun L. W. ;
Alexander, Gene E. ;
Scheltens, Philip ;
Vellas, Bruno ;
Dubois, Bruno ;
Weiner, Michael ;
Hampel, Harald .
NEUROBIOLOGY OF AGING, 2012, 33 (07) :1203-+
[43]   Deep Learning and Risk Score Classification of Mild Cognitive Impairment and Alzheimer's Disease [J].
Nagaraj, Sanjay ;
Duong, Tim Q. .
JOURNAL OF ALZHEIMERS DISEASE, 2021, 80 (03) :1079-1090
[44]   The cognitive and neural expression of semantic memory impairment in mild cognitive impairment and early Alzheimer's disease [J].
Joubert, Sven ;
Brambati, Simona M. ;
Ansado, Jennyfer ;
Barbeau, Emmanuel J. ;
Felician, Olivier ;
Didic, Mira ;
Lacombe, Jacinthe ;
Goldstein, Rachel ;
Chayer, Celine ;
Kergoat, Marie-Jeanne .
NEUROPSYCHOLOGIA, 2010, 48 (04) :978-988
[45]   Nonlinear biomarker interactions in conversion from mild cognitive impairment to Alzheimer's disease [J].
Popescu, Sebastian G. ;
Whittington, Alex ;
Gunn, Roger N. ;
Matthews, Paul M. ;
Glocker, Ben ;
Sharp, David J. ;
Cole, James H. .
HUMAN BRAIN MAPPING, 2020, 41 (15) :4406-4418
[46]   Memory complaints in subjective cognitive impairment, amnestic mild cognitive impairment and mild Alzheimer’s disease [J].
Seon Young Ryu ;
Sang Bong Lee ;
Tae Woo Kim ;
Taek Jun Lee .
Acta Neurologica Belgica, 2016, 116 :535-541
[47]   Anosognosia Is an Independent Predictor of Conversion From Mild Cognitive Impairment to Alzheimer's Disease and Is Associated With Reduced Brain Metabolism [J].
Gerretsen, Philip ;
Chung, Jun Ku ;
Shah, Parita ;
Plitman, Eric ;
Iwata, Yusuke ;
Caravaggio, Fernando ;
Nakajima, Shinichiro ;
Pollock, Bruce G. ;
Graff-Guerrero, Ariel .
JOURNAL OF CLINICAL PSYCHIATRY, 2017, 78 (09) :E1187-+
[48]   Genetic risk score predicting accelerated progression from mild cognitive impairment to Alzheimer's disease [J].
Rodriguez-Rodriguez, E. ;
Sanchez-Juan, P. ;
Vazquez-Higuera, J. L. ;
Mateo, I. ;
Pozueta, A. ;
Berciano, J. ;
Cervantes, S. ;
Alcolea, D. ;
Martinez-Lage, P. ;
Clarimon, J. ;
Lleo, A. ;
Pastor, P. ;
Combarros, O. .
JOURNAL OF NEURAL TRANSMISSION, 2013, 120 (05) :807-812
[49]   Association Between Polygenic Risk Score and the Progression from Mild Cognitive Impairment to Alzheimer's Disease [J].
Liu, Hongliang ;
Lutz, Michael ;
Luo, Sheng .
JOURNAL OF ALZHEIMERS DISEASE, 2021, 84 (03) :1323-1335
[50]   Cognitive complaint in mild cognitive impairment and Alzheimer's disease [J].
Clement, Francis ;
Belleville, Sylvie ;
Gauthier, Serge .
JOURNAL OF THE INTERNATIONAL NEUROPSYCHOLOGICAL SOCIETY, 2008, 14 (02) :222-232