An overview of systematic reviews found suboptimal reporting and methodological limitations of mediation studies investigating causal mechanisms

被引：25

作者：

Cashin, Aidan G. ^{[1
,2
]}

Lee, Hopin ^{[3
,4
,5
]}

Lamb, Sarah E. ^{[3
]}

Hopewell, Sally ^{[3
]}

Mansell, Gemma ^{[6
]}

Williams, Christopher M. ^{[4
,5
]}

Kamper, Steven J. ^{[5
,7
]}

Henschke, Nicholas ^{[7
]}

McAuley, James H. ^{[1
,8
]}

机构：

[1] Neurosci Res Australia, Pain Res Educ & Management Program, Sydney, NSW, Australia

[2] Univ New South Wales, Fac Med, Prince Wales Clin Sch, Sydney, NSW, Australia

[3] Univ Oxford, NDORMS, Ctr Stat Med & Rehabil Res Oxford, Oxford, England

[4] Univ Newcastle, Sch Med & Publ Hlth, Newcastle, NSW, Australia

[5] CPHL, New Lambton Hts, Australia

[6] Aston Univ, Sch Life & Hlth Sci, Dept Psychol, Birmingham, W Midlands, England

[7] Univ Sydney, Sch Publ Hlth, Sydney, NSW, Australia

[8] Univ New South Wales, Sch Med Sci, Fac Med, Sydney, NSW, Australia

来源：

JOURNAL OF CLINICAL EPIDEMIOLOGY | 2019年 / 111卷

基金：

英国医学研究理事会;

关键词：

Mechanism; Mediation analysis; Overview; Quality of reporting; Causal inference; Health care; PHYSICAL-ACTIVITY; BEHAVIOR-CHANGE; SELF-REGULATION; BLOOD-GLUCOSE; INTERVENTIONS; HEALTH; ASSOCIATION; DISORDER; METAANALYSIS; GUIDELINES;

D O I：

10.1016/j.jclinepi.2019.03.005

中图分类号：

R19 [保健组织与事业（卫生事业管理）];

学科分类号：

摘要：

Objectives: The objective of this study was to investigate whether systematic reviews of mediation studies identify limitations in reporting quality and methodological conduct. Study Design and Setting: We conducted an overview of systematic reviews. We searched four databases (MEDLINE, PsycINFO, Cochrane Database of Systematic Reviews, and PubMed) to identify systematic reviews of studies that used mediation analysis to investigate mechanisms of health care interventions or exposures in clinical populations between 2007 and 2017. Two reviewers independently screened titles and abstracts. Summary data on the characteristics, reporting quality, and methodological conduct of the studies included in the systematic reviews were extracted independently by two reviewers. The protocol was prospectively registered on PROSPERO (CRD42017059834). Results: Fifty-four systematic reviews were included, representing 11 health care fields, 26 health conditions, and 2008 mediation studies. Eighteen of fifty-four systematic reviews (33%) explicitly stated that the reporting of primary studies was suboptimal. Of these, 14/18 (78%) reviews noted incomplete reporting of effect sizes and precision estimates from mediation analyses. Twenty-nine of fifty-four systematic reviews (54%) identified limitations in the methodological conduct of primary studies. Conclusion: The reporting and methodological conduct of studies investigating mechanisms in health care seems to be suboptimal. Guidance is needed to improve the quality, completeness, and transparency of mediation studies. (C) 2019 Elsevier Inc. All rights reserved.

引用

页码：60 / 68

页数：9

共 83 条

[1] Diabetes and Incident Depression: Is the Association Mediated or Modified by Sociodemographic Factors or Co-morbidities? A Systematic Review [J].

Albers, B. ;

Kruse, J. ;

Giani, G. ;

Icks, A. .

EXPERIMENTAL AND CLINICAL ENDOCRINOLOGY & DIABETES, 2011, 119 (10) :591-598

[2] EQUATOR: reporting guidelines for health research [J].

Altman, Douglas G. ;

Simera, Iveta ;

Hoey, John ;

Moher, David ;

Schutz, Ken .

LANCET, 2008, 371 (9619) :1149-1150

[3]

[Anonymous], CAN J ANESTH

[4]

[Anonymous], 2015, EXPLANATION CAUSAL I

[5]

[Anonymous], 2016, NEWCASTLE OTTAWA SCA

[6]

[Anonymous], J PSYCHOSOC ONCOL

[7]

[Anonymous], HLTH TECHNOL ASSESS

[8] Efficacy of selective serotonin reuptake inhibitors and adverse events: meta-regression and mediation analysis of placebo-controlled trials [J].

Barth, Michael ;

Kriston, Levente ;

Klostermann, Swaantje ;

Barbui, Corrado ;

Cipriani, Andrea ;

Linde, Klaus .

BRITISH JOURNAL OF PSYCHIATRY, 2016, 208 (02) :114-119

[9] Mechanisms of Change in Adolescent Substance Use Treatment: How Does Treatment Work? [J].

Black, Jessica J. ;

Chung, Tammy .

SUBSTANCE ABUSE, 2014, 35 (04) :344-351

[10] Using the Common Sense Model of Self-Regulation to Review the Effects of Self-Monitoring of Blood Glucose on Glycemic Control for Non-Insulin-Treated Adults With Type 2 Diabetes [J].

Breland, Jessica Y. ;

McAndrew, Lisa M. ;

Burns, Edith ;

Leventhal, Elaine A. ;

Leventhal, Howard .

DIABETES EDUCATOR, 2013, 39 (04) :541-559

← 1 2 3 4 5 6 7 8 9 →