Interleukin-33 Promotes Serotonin Release from Enterochromaffin Cells for Intestinal Homeostasis

被引：99

作者：

Chen, Zuojia ^{[1
]}

Luo, Jialie ^{[1
]}

Li, Jian ^{[1
]}

Kim, Girak ^{[1
]}

Stewart, Andy ^{[2
]}

Urban, Joseph F., Jr. ^{[3
]}

Huang, Yuefeng ^{[4
,8
]}

Chen, Shan ^{[5
]}

Wu, Ling-Gang ^{[6
]}

Chesler, Alexander ^{[7
]}

Trinchieri, Giorgio ^{[2
]}

Li, Wei ^{[5
]}

Wu, Chuan ^{[1
]}

机构：

[1] NCI, Expt Immunol Branch, NIH, Bldg 10, Bethesda, MD 20892 USA

[2] NCI, Canc & Inflammat Program, Ctr Canc Res, NIH, Bethesda, MD 20892 USA

[3] ARS, USDA, Beltsville Human Nutr Res Ctr, Diet Genom & Immunol Lab, Beltsville, MD USA

[4] NIAID, Lab Immunol, NIH, 9000 Rockville Pike, Bethesda, MD 20892 USA

[5] NEI, Retinal Neurophysiol Sect, NIH, Bethesda, MD 20892 USA

[6] NINDS, Synapt Transmiss Sect, NIH, Bldg 36,Rm 4D04, Bethesda, MD 20892 USA

[7] NIH, Sensory Cells & Circuits Sect, Natl Ctr Complementary & Integrat Hlth, Bldg 10, Bethesda, MD 20892 USA

[8] Columbia Univ, Dept Microbiol & Immunol, New York, NY USA

来源：

IMMUNITY | 2021年 / 54卷 / 01期

关键词：

IL-13; PRODUCTION; IL-33; RECEPTOR; DYSFUNCTION; RESPONSES; NEURONS; SYSTEM; MODEL; DIFFERENTIATION; CHEMOTHERAPY;

D O I：

10.1016/j.immuni.2020.10.014

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The gastrointestinal tract is known as the largest endocrine organ that encounters and integrates various immune stimulations and neuronal responses due to constant environmental challenges. Enterochromaffin (EC) cells, which function as chemosensors on the gut epithelium, are known to translate environmental cues into serotonin (5-HT) production, contributing to intestinal physiology. However, how immune signals participate in gut sensation and neuroendocrine response remains unclear. Interleukin-33 (IL-33) acts as an alarmin cytokine by alerting the system of potential environmental stresses. We here demonstrate that IL-33 induced instantaneous peristaltic movement and facilitated Trichuris muris expulsion. We found that IL-33 could be sensed by EC cells, inducing release of 5-HT. IL-33-mediated 5-HT release activated enteric neurons, subsequently promoting gut motility. Mechanistically, IL-33 triggered calcium influx via a non canonical signaling pathway specifically in EC cells to induce 5-HT secretion. Our data establish an immune-neuroendocrine axis in calibrating rapid 5-HT release for intestinal homeostasis.

引用

页码：151 / +

页数：19

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