Endocytosis, asymmetric cell division, stem cells and cancer: Unus pro omnibus, omnes pro uno

被引：23

作者：

Fuerthauer, Maximilian ^{[1
,2
]}

Gonzalez-Gaitan, Marcos ^{[1
,2
]}

机构：

[1] Univ Geneva, Dept Mol Biol, CH-1211 Geneva 4, Switzerland

[2] Univ Geneva, Dept Biochem, CH-1211 Geneva, Switzerland

来源：

MOLECULAR ONCOLOGY | 2009年 / 3卷 / 04期

关键词：

Endocytosis; Asymmetric cell division; Cancer; Stem cells; Delta/Notch signalling; NEUROBLAST SELF-RENEWAL; HUMAN HEMATOPOIETIC STEM; ACUTE MYELOID-LEUKEMIA; FATE DETERMINANT NUMB; TUMOR-SUPPRESSOR; SPINDLE ORIENTATION; DROSOPHILA NEUROGENESIS; MEMBRANE LOCALIZATION; NOTCH TRAFFICKING; PROGENITOR CELLS;

D O I：

10.1016/j.molonc.2009.05.006

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Carcinogenesis can be initiated in adult stem cells, suggesting that tumours arise as a consequence of stem-cell dysfunction. in the fruitfly, cancer arises in stem cells that fail to undergo asymmetric cell division. In flies and mammals, a specific regulation of the endocytic trafficking machinery allows stem cells to self-renew and generate the differentiating cells required to form and maintain mature organs. We review recent findings suggesting that an understanding of the relationship between endocytosis, asymmetric cell division, stem cells and cancer will be crucial to unravel the cell biological basis of tumourigenesis. (C) 2009 Federation of European Biochemical Societies. Published by Elsevier B.V. All rights reserved.

引用

页码：339 / 353

页数：15

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