Surgery, Stereotactic Radiosurgery, and Systemic Therapy in the Management of Operable Brain Metastasis

被引:13
作者
Kotecha, Rupesh [2 ]
Ahluwalia, Manmeet S. [1 ,2 ,3 ]
Siomin, Vitaly [2 ,4 ]
McDermott, Michael W. [2 ,4 ,5 ]
机构
[1] Miami Canc Inst, Dept Radiat Oncol, Baptist Hlth South Florida, Miami, FL USA
[2] Florida Int Univ, Herbert Wertheim Coll Med, Miami, FL USA
[3] Miami Canc Inst, Dept Med Oncol, Baptist Hlth South Florida, Miami, FL USA
[4] Miami Neurosci Inst, Div Neurosurg, Baptist Hlth South Florida, 8950 North Kendall Dr Suite 407 West, Miami, FL USA
[5] Miami Neurosci Inst, Baptist Hlth South Florida, 8950 Kendall Dr Suite 407 West, Miami, FL 33176 USA
关键词
Stereotactic radiosurgery; Surgery; Targeted therapy; Immunotherapy; Brain metastases; POSTOPERATIVE RESECTION CAVITY; INTRAOPERATIVE CESIUM-131 BRACHYTHERAPY; SURGICAL RESECTION; NEOADJUVANT RADIOSURGERY; CEREBRAL METASTASES; SINGLE METASTASES; RADIOTHERAPY; EXPRESSION; EVOLUTION; CANCER;
D O I
10.1016/j.ncl.2021.11.002
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
center dot Brain metastases represent the most common brain tumors in adults. center dot Recent advances in our understanding of the molecular biology of metastases versus pri-mary tumors have allowed for tailoring systemic therapies in those with actionable alter-ations and the introduction of immunotherapies has provided additional treatment options for a broad range of malignancies. center dot Technical advances in surgical techniques with intraoperative image guidance and elec-trophysiologic mapping have improved surgical outcomes and innovative radiotherapy approaches, such as preoperative or postoperative stereotactic radiosurgery, continue to improve local control rates. center dot Given the complexity of managing operable patients with brain metastases in the modern era, multi-disciplinary care is critical to improving patient outcomes.
引用
收藏
页码:421 / 436
页数:16
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