IL-17 and IL-22 are associated with protection against human kala azar caused by Leishmania donovani

被引：225
作者：
Pitta, Maira G. R. [2 ,3 ]
Romano, Audrey [2 ,3 ]
Cabantous, Sandrine [2 ,3 ]
Henri, Sandrine [2 ]
Hammad, Awad [4 ]
Kouriba, Bourema [2 ]
Argiro, Laurent [2 ,3 ]
el Kheir, Musa [4 ]
Bucheton, Bruno [2 ]
Mary, Charles [2 ,5 ]
El-Safi, Sayda Hassan [4 ]
Dessein, Alain [1 ,2 ,3 ,4 ]
机构：
[1] INSERM, Timone Fac Med, UMR 906, U906, F-13385 Marseille, France
[2] Aix Marseille Univ, Fac Med, UMR 906, Marseille, France
[3] Inst Microbiol Mediterranee, IFR88, Marseille, France
[4] Univ Khartoum, Fac Med, Dept Med Microbiol & Parasitol, Khartoum, Sudan
[5] CHU Timone, Lab Parasitol Mycol, Hop Marseille, Marseille, France
来源：
JOURNAL OF CLINICAL INVESTIGATION | 2009年 / 119卷 / 08期
关键词：
IL-17-PRODUCING T-CELLS; VISCERAL LEISHMANIASIS; TH17; CELLS; HOST-DEFENSE; AUTOIMMUNE ENCEPHALOMYELITIS; CUTANEOUS LEISHMANIASIS; KLEBSIELLA-PNEUMONIAE; INTERFERON-GAMMA; IMMUNE-RESPONSE; EASTERN SUDAN;
D O I：
10.1172/JCI38813
中图分类号：
R-3 [医学研究方法]; R3 [基础医学];
学科分类号：
1001 ;
摘要：
IL-17 and IL-22 have been shown to increase protection against certain bacteria and fungal pathogens in experimental models. However, no human studies have demonstrated a crucial role of IL-17 and IL-22 in protection against infections. We show here that Leishmania donovani, which can cause the lethal visceral disease Kala Azar (KA), stimulates the differentiation of Th17 cells, which produce IL-17, IL-22, and IFN-gamma. Analysis of Th1, Th2, and Th17 cytokine responses by cultured PBMCs from individuals in a cohort of subjects who developed KA or were protected against KA during a severe outbreak showed that IL-17 and IL-22 were strongly and independently associated with protection against KA. Our results suggest that, along with Th1 cytokines, IL-17 and IL-22 play complementary roles in human protection against KA, and that a defect in Th17 induction may increase the risk of KA.
引用
收藏
页码：2379 / 2387
页数：9
相关论文
共 47 条
  • [1] Surface phenotype and antigenic specificity of human interleukin 17-producing T helper memory cells
    Acosta-Rodriguez, Eva V.
    Rivino, Laura
    Geginat, Jens
    Jarrossay, David
    Gattorno, Marco
    Lanzavecchia, Antonio
    Sallusto, Federica
    Napolitani, Giorgio
    [J]. NATURE IMMUNOLOGY, 2007, 8 (06) : 639 - 646
  • [2] Phenotypic and functional features of human Th17 cells
    Annunziato, Francesco
    Cosmi, Lorenzo
    Santarlasci, Veronica
    Maggi, Laura
    Liotta, Francesco
    Mazzinghi, Benedetta
    Parente, Eliana
    Fili, Lucia
    Ferri, Simona
    Frosali, Francesca
    Giudici, Francesco
    Romagnani, Paola
    Parronchi, Paola
    Tonelli, Francesco
    Maggi, Enrico
    Romagnani, Sergio
    [J]. JOURNAL OF EXPERIMENTAL MEDICINE, 2007, 204 (08) : 1849 - 1861
  • [3] Elevated levels of interferon-γ, interleukin-10, interleukin-6 during active disease in Indian kala azar
    Ansari, Nasim Akhtar
    Saluja, Sumita
    Salotra, Poonam
    [J]. CLINICAL IMMUNOLOGY, 2006, 119 (03) : 339 - 345
  • [4] Interleukin-12 restores interferon-gamma production and cytotoxic responses in visceral leishmaniasis
    Bacellar, O
    Brodskyn, C
    Guerreiro, J
    BarralNetto, M
    Costa, CH
    Coffman, RL
    Johnson, WD
    Carvalho, EM
    [J]. JOURNAL OF INFECTIOUS DISEASES, 1996, 173 (06) : 1515 - 1518
  • [5] IL-22 inhibits epidermal differentiation and induces proinflammatory gene expression and migration of human keratinocytes
    Boniface, K
    Bernard, FX
    Garcia, M
    Gurney, AL
    Lecron, JC
    Morel, F
    [J]. JOURNAL OF IMMUNOLOGY, 2005, 174 (06) : 3695 - 3702
  • [6] The interplay between environmental and host factors during an outbreak of visceral leishmaniasis in eastern Sudan
    Bucheton, B
    Kheir, MM
    El-Safi, SH
    Hammad, A
    Mergani, A
    Mary, C
    Abel, L
    Dessein, A
    [J]. MICROBES AND INFECTION, 2002, 4 (14) : 1449 - 1457
  • [7] Cutting edge: IL-21 is not essential for Th17 differentiation or experimental autoimmune encephalomyelitis
    Coquet, Jonathan M.
    Chakravarti, Sumone
    Smyth, Mark J.
    Godfrey, Dale I.
    [J]. JOURNAL OF IMMUNOLOGY, 2008, 180 (11) : 7097 - 7101
  • [8] TH 17 cells in development:: an updated view of their molecular identity and genetic programming
    Dong, Chen
    [J]. NATURE REVIEWS IMMUNOLOGY, 2008, 8 (05) : 337 - 348
  • [9] Epidemiology of visceral leishmaniasis in Atbara River area, eastern Sudan: the outbreak of Barbar El Fugara village (1996-1997)
    El-Safi, SH
    Bucheton, B
    Kheir, MM
    Musa, HAA
    El-Obaid, M
    Hammad, A
    Dessein, A
    [J]. MICROBES AND INFECTION, 2002, 4 (14) : 1439 - 1447
  • [10] Distinct immunity in patients with visceral leishmaniasis from that in subclinically infected and drug-cured people: Implications for the mechanism underlying drug cure
    Hailu, A
    Menon, JN
    Berhe, N
    Gedamu, L
    Hassard, TH
    Kager, PA
    Olobo, J
    Bretscher, PA
    [J]. JOURNAL OF INFECTIOUS DISEASES, 2001, 184 (01) : 112 - 115
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