Tricetin, a Dietary Flavonoid, Inhibits Proliferation of Human Breast Adenocarcinoma MCF-7 Cells by Blocking Cell Cycle Progression and Inducing Apoptosis

被引：49
|
作者：
Hsu, Ya-Ling [2 ]
Uen, Yih-Huei [3 ]
Chen, Yi [3 ]
Liang, Hsin-Lin [4 ]
Kuo, Po-Lin [1 ,5 ]
机构：
[1] Kaohsiung Med Univ, Coll Med, Inst Clin Med, Kaohsiung 807, Taiwan
[2] Kaohsiung Med Univ, Coll Med, Grad Inst Med, Kaohsiung 807, Taiwan
[3] Chi Mei Fdn, Med Ctr, Dept Surg, Div Gen Surg, Young Kang City 710, Tainan, Taiwan
[4] Kaohsiung Municipal United Hosp, Dept Pharmacol, Kaohsiung 804, Taiwan
[5] Kaohsiung Med Univ Hosp, Dept Med Res, Kaohsiung 807, Taiwan
来源：
JOURNAL OF AGRICULTURAL AND FOOD CHEMISTRY | 2009年 / 57卷 / 18期
关键词：
Tricetin; ATM; p53; cell cycle; apoptosis; DNA-DAMAGE; EUCALYPTUS HONEYS; CANCER CELLS; P53; PROTEIN; PHOSPHORYLATION; ARREST; ATM; ACTIVATION; CHECKPOINT; PATHWAY;
D O I：
10.1021/jf901053x
中图分类号：
S [农业科学];
学科分类号：
09 ;
摘要：
This study is the first to investigate the anticancer effect of tricetin in human breast adenocarcinoma (ATM). Activation of ATM by tricetin phosphorylated p53 at serine 15. (MDM2) interaction. In addition, tricetin-mediated G2/M phase arrest was also associated with decreases in (serine 15) and Chk2. Tricetin-induced apoptotic cell
引用
收藏
页码：8688 / 8695
页数：8
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