Synthesis of cyclic ethers utilizing a cyclization-fragmentation strategy

被引：8

作者：

Ockey, DA ^{[1
]}

Lane, DR ^{[1
]}

Seeley, JA ^{[1
]}

Schore, NE ^{[1
]}

机构：

[1] Univ Calif Davis, Dept Chem, Davis, CA 95616 USA

来源：

TETRAHEDRON | 2000年 / 56卷 / 05期

基金：

美国国家科学基金会;

关键词：

cyclization; ethers; isoxazolines; nitrile oxides; polymer support;

D O I：

10.1016/S0040-4020(99)01063-7

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A variety of cyclic ethers have been prepared via both solution phase and polymer-supported sequences of 3 + 2 cycloaddition of nitrile oxides to alkenes and dienes to give isoxazolines, followed by electrophile-induced cyclization. Library generation by alkylative elaboration of isoxazolines was unsuccessful, but both simple and substituted dienes were found suitable for polymer-supported formation of cyclic ethers of ring sizes five through seven. (C) 2000 Elsevier Science Ltd. All rights reserved.

引用

页码：711 / 717

页数：7

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