New Strategies in Ovarian Cancer: Translating the Molecular Complexity of Ovarian Cancer into Treatment Advances

被引：102

作者：

Liu, Joyce ^{[1
]}

Matulonis, Ursula A. ^{[1
]}

机构：

[1] Dana Farber Canc Inst, Dept Med Oncol, Gynecol Oncol Program, Boston, MA 02215 USA

来源：

CLINICAL CANCER RESEARCH | 2014年 / 20卷 / 20期

关键词：

OLAPARIB MAINTENANCE THERAPY; NEGATIVE BREAST-CANCER; FOCAL ADHESION KINASE; EPITHELIAL OVARIAN; OPEN-LABEL; FALLOPIAN-TUBE; PRIMARY PERITONEAL; DOUBLE-BLIND; RECURRENT; BEVACIZUMAB;

D O I：

10.1158/1078-0432.CCR-14-1312

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

An improved understanding of the genomics of ovarian cancer and the separation of ovarian cancer into histologically and molecularly defined subgroups have affected drug development and clinical trial design in ovarian cancer. Active therapies that have been tested in ovarian cancer include agents that inhibit angiogenesis and poly (ADP-ribose) polymerase inhibitors (PARPi). However, no FDA drug approvals for ovarian cancer have been granted since 2006, and overall survival improvements have been difficult to achieve with new agents. The genomic complexity of ovarian cancer and modest single-agent activity of many biologic agents in this disease have led to testing of biologic agent combinations. In this article, we review recent advances in the understanding of the molecular diversity of ovarian cancer as well as emerging therapeutic strategies such as new agents and biologic combinations that attempt to target multiple aberrant pathways in this cancer. (C)2014 AACR.

引用

页码：5150 / 5156

页数：7

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