An efficient synthesis of 1,5-thiadiazepines and 1,5-benzodiazepines by microwave-assisted heterocyclization

被引：24

作者：

Nagaraja, Gundibasappa K.

Vaidya, Vijayavittala P.

Rai, Koodamara Sheshappa

Mahadevan, Kittappa M. ^{[1
]}

机构：

[1] Kuvempu Univ, Dept Postgrad Studies & Res Chem, Shimoga 577451, Karnataka, India

[2] Univ Mysore, Sir MV PG Ctr, Dept PG Studies & Res Polymer Sci, Mandya, Karnataka, India

来源：

PHOSPHORUS SULFUR AND SILICON AND THE RELATED ELEMENTS | 2006年 / 181卷 / 12期

关键词：

1-amino-2-mercapto-5-aryl-1,3,4-triazole; chalcones; heterocycliczation; microwave irradiation; o-phenylenediamine;

D O I：

10.1080/10426500600864775

中图分类号：

O61 [无机化学];

学科分类号：

070301 ; 081704 ;

摘要：

A novel and efficient method for the synthesis of substituted thiazepines and diazepines has been developed. A simple one-pot reaction of chalcones 1a-f with 1-amino-2-mercapto-5-phenyl-1,3,4-triazole and o-phenylenediamine in the presence of a catalytic amount of sodium acetate under microwave irradiation gave 2-(3,8-diphenyl-7,8-dihydro[1,2,4]triazolo[3,4-b][1,3,4]thiadiazepin-6-yl)phenoles 2a-f and 2-(2-phenyl-2,3-dihydro-1H-1,5-benzodiazepin-4-yl)phenoles 3a-f, respectively. The structure of all the synthesized compounds was elucidated on the basis of elemental analysis, IR, H-1 and C-13 NMR, and mass spectral data.

引用

页码：2797 / 2806

页数：10