Anxiolytic-like Effects of Ginsenosides Rg3 and Rh2 from Red Ginseng in the Elevated Plus-Maze Model

被引：29

作者：

Kim, Tae Woo ^{[3
]}

Choi, Hyuck-Jai ^{[4
]}

Kim, Nam-Jae ^{[4
]}

Kim, Dong-Hyun ^{[1
,2
]}

机构：

[1] Kyung Hee Univ, Dept Life & Nanopharmaceut Sci, Seoul 130701, South Korea

[2] Kyung Hee Univ, Coll Pharm, Seoul 130701, South Korea

[3] Gu Jeong High Sch, Seoul, South Korea

[4] Kyung Hee Univ, Kyung Hee Med Ctr, EW Med Res Inst, Seoul 130701, South Korea

来源：

PLANTA MEDICA | 2009年 / 75卷 / 08期

关键词：

Panax ginseng; Araliaceae; anxiety; red ginseng; ginsenoside Rg3; ginsenoside Rh2; CONSTITUENTS; INGREDIENTS;

D O I：

10.1055/s-0029-1185402

中图分类号：

Q94 [植物学];

学科分类号：

071001 ;

摘要：

The anxiolytic-like effects of red ginseng (RG, the steamed root of Panax ginseng, family Araliaceae), its saponin fraction, and its representative constituents, ginsenosides Rg3 and Rh2, were investigated in mice using the elevated plus-maze test. These agents significantly increased the time spent on the open arms and the number of open-arm entries. The anxiolytic-like activities of Rg3 and Rh2 were antagonized by flumazenil but not by WAY-100635. RG and its constituents, Rg3 and Rh2, may exert anxiolytic effects by antagonizing GABA/benzodiazepines.

引用

页码：836 / 839

页数：4

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