The kinetics of proinflammatory cytokines in murine peritoneal macrophages infected with envelope protein-glycosylated or non-glycosylated West Nile virus

被引：12

作者：

Shirato, Kazuya

Miyoshi, Hirotsugu

Kariwa, Hiroaki

Takashima, Ikuo

机构：

[1] Hokkaido Univ, Grad Sch Vet Med, Dept Environm Vet Sci, Lab Publ Hlth,Kita Ku, Sapporo, Hokkaido 0600818, Japan

[2] Natl Inst Infect Dis, Murayama Branch, Dept Virol 3, Lab Acute Resp Viral Dis & Cytokines, Tokyo, Japan

来源：

VIRUS RESEARCH | 2006年 / 121卷 / 01期

关键词：

envelope protein glycosylation; peritoneal macrophage; tumor necrosis factor alpha (TNF alpha); West Nile virus;

D O I：

10.1016/j.virusres.2006.03.010

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The envelope (E) protein glycosylation status of the New York strain of West Nile (WN) virus is an important determinant of virus neuroinvasiveness. To elucidate the determinant of the difference between E protein-glycosylated and non-glycosylated WN virus infections, the cytokine expression of murine peritoneal macrophages infected with each virus was examined. Tumor necrosis factor (TNF) alpha and interleukin (IL)-1 beta were up-regulated with replication of the E protein-glycosylated virus. Interferon (IFN) beta and IL-6 were up-regulated with the clearance of both viruses. These results suggest that TNF alpha and IL-1 beta expression are related to the virulence of E protein-glycosylated WN virus. (c) 2006 Elsevier B.V. All rights reserved.

引用

页码：11 / 16

页数：6

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