Dectin-1 activation induces proliferation and migration of human keratinocytes enhancing wound re-epithelialization

被引：53
作者：
van den Berg, Linda M. [1 ]
Zijlstra-Willems, Esther M. [1 ]
Richters, Cornelia D. [2 ,5 ]
Ulrich, Magda M. W. [3 ,4 ]
Geijtenbeek, Teunis B. H. [1 ]
机构：
[1] Univ Amsterdam, Acad Med Ctr, Dept Expt Immunol, NL-1105 AZ Amsterdam, Netherlands
[2] Vrije Univ Amsterdam, Med Ctr, Dept Mol Cell Biol & Immunol, Amsterdam, Netherlands
[3] Vrije Univ Amsterdam, Med Ctr, Dept Plast Reconstruct & Hand Surg, Amsterdam, Netherlands
[4] Assoc Dutch Burn Ctr, Beverwijk, Netherlands
[5] Euro Skin Bank, Beverwijk, Netherlands
来源：
CELLULAR IMMUNOLOGY | 2014年 / 289卷 / 1-2期
关键词：
Keratinocytes; Dectin-1; Beta-glucans; Proliferation; Migration; Wound healing; TOLL-LIKE RECEPTORS; EXPRESSION; IMMUNITY; RECOGNITION; FUNGAL; KINASE; CELLS; SKIN;
D O I：
10.1016/j.cellimm.2014.03.007
中图分类号：
Q2 [细胞生物学];
学科分类号：
071009 ; 090102 ;
摘要：
Beta-glucans in temporary wound dressings have immuno-stimulatory capacities and have been shown to enhance wound healing in burn patients. Curdlan is a 1,3-linked bacterial/fungal derived beta-glucan that induces inflammatory responses via the C-type lectin receptor dectin-1 on dendritic cells (DCs). Here we investigated the effect of beta-glucan curdlan and the role of dectin-1 expressed by keratinocytes (KCs) in wound healing. Curdlan enhanced migration, proliferation and wound closure of human KCs in a dectin-1 dependent manner, both in vitro and ex vivo. Our data suggest that curdlan induces human KC proliferation and migration and could therefore be used in creams to enhance wound healing. (C) 2014 Elsevier Inc. All rights reserved.
引用
收藏
页码：49 / 54
页数：6
相关论文
共 22 条
[1]  
[Anonymous], J ALTERN COMPLEMENT
[2]   Immune recognition -: A new receptor for β-glucans [J].
Brown, GD ;
Gordon, S .
NATURE, 2001, 413 (6851) :36-37
[3]   Structure of the fungal β-glucan-binding immune receptor dectin-1:: Implications for function [J].
Brown, James ;
O'Callaghan, Chris A. ;
Marshall, Andrew S. J. ;
Gilbert, Robert J. C. ;
Siebold, Christian ;
Gordon, Siamon ;
Brown, Gordon D. ;
Jones, E. Yvonne .
PROTEIN SCIENCE, 2007, 16 (06) :1042-1052
[4]   Development of an in vitro burn wound model [J].
Coolen, Neeltje A. ;
Vlig, Marcel ;
van den Bogaerdt, Antoon J. ;
Middelkoop, Esther ;
Ulrich, Magda M. W. .
WOUND REPAIR AND REGENERATION, 2008, 16 (04) :559-567
[5]   Cosmeceuticals and natural products: wound healing [J].
Davis, Stephen C. ;
Perez, Robert .
CLINICS IN DERMATOLOGY, 2009, 27 (05) :502-506
[6]   Epidermal Expression of Host Response Genes upon Skin Barrier Disruption in Normal Skin and Uninvolved Skin of Psoriasis and Atopic Dermatitis Patients [J].
de Koning, Heleen D. ;
Kamsteeg, Marijke ;
Rodijk-Olthuis, Diana ;
van Vlijmen-Willems, Ivonne M. J. J. ;
van Erp, Piet E. J. ;
Schalkwijk, Joost ;
Zeeuwen, Patrick L. J. M. .
JOURNAL OF INVESTIGATIVE DERMATOLOGY, 2011, 131 (01) :263-266
[7]   Effectiveness of beta-glucan collagen for treatment of partial-thickness burns in children [J].
Delatte, SJ ;
Evans, J ;
Hebra, A ;
Adamson, W ;
Othersen, HB ;
Tagge, EP .
JOURNAL OF PEDIATRIC SURGERY, 2001, 36 (01) :113-118
[8]   Syk kinase is required for collaborative cytokine production induced through Dectin-1 and Toll-like receptors [J].
Dennehy, Kevin M. ;
Ferwerda, Gerben ;
Faro-Trindade, Ines ;
Pyz, Elwira ;
Willment, Janet A. ;
Taylor, Philip R. ;
Kerrigan, Ann ;
Tsoni, S. Vicky ;
Gordon, Siamon ;
Meyer-Wentrup, Friederike ;
Adema, Gosse J. ;
Kullberg, Bart-Jan ;
Schweighoffer, Edina ;
Tybulewicz, Victor ;
Mora-Montes, Hector M. ;
Gow, Neil A. R. ;
Williams, David L. ;
Netea, Mihai G. ;
Brown, Gordon D. .
EUROPEAN JOURNAL OF IMMUNOLOGY, 2008, 38 (02) :500-506
[9]   C-type lectin DC-SIGN modulates toll-like receptor signaling via Raf-1 kinase-dependent acetylation of transcription factor NF-κB [J].
Gringhuis, Sonja I. ;
den Dunnen, Jeroen ;
Litjens, Manja ;
Hof, Bert van het ;
van Kooyk, Yvette ;
Geijtenbeek, Teunis B. H. .
IMMUNITY, 2007, 26 (05) :605-616
[10]   Carbohydrate-specific signaling through the DC-SIGN signalosome tailors immunity to Mycobacterium tuberculosis, HIV-1 and Helicobacter pylori [J].
Gringhuis, Sonja I. ;
den Dunnen, Jeroen ;
Litjens, Manja ;
van der Vlist, Michiel ;
Geijtenbeek, Teunis B. H. .
NATURE IMMUNOLOGY, 2009, 10 (10) :1081-U58
123