A general metal free approach to α-ketoamides via oxidative amidation-diketonization of terminal alkynes

被引：107

作者：

Deshidi, Ramesh ^{[1
]}

Kumar, Manjeet ^{[1
]}

Devari, Shekaraiah ^{[1
]}

Shah, Bhahwal Ali ^{[1
]}

机构：

[1] CSIR, Indian Inst Integrat Med, Acad Sci & Innovat Res AcSIR, Jammu 180001, India

来源：

CHEMICAL COMMUNICATIONS | 2014年 / 50卷 / 67期

关键词：

METHYL KETONES; FACILE ACCESS; ACETOPHENONES; INHIBITORS; AMINES; DERIVATIVES; FORMAMIDES; ACIDS; NIS;

D O I：

10.1039/c4cc03783a

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

A novel catalytic system TMSOTf/I-2/DMSO for the oxidative coupling of terminal alkynes with virtually any primary/secondary amine leading to alpha-ketoamides has been developed. The reaction possibly proceeds via iminium ion formation, wherein DMSO acts as a solvent as well as an oxidizing agent.

引用

页码：9533 / 9535

页数：3

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