Mechanisms of the airway hyperresponsiveness induced by Strongyloides venezuelensis infection in rats: role of capsaicin-sensitive neurons

被引：3

作者：

Ferreira, Caroline M. ^{[1
]}

Pereira, Ana-Terezinha M. ^{[2
]}

Amaral, Flavio A. ^{[1
]}

de Souza, Rafael S. ^{[1
]}

Coelho, Fernanda Matos ^{[1
]}

Souza, Danielle G. ^{[3
]}

Negrao-Correa, Deborah ^{[2
]}

Teixeira, Mauro M. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 02期

关键词：

Helminth; Airway hyperreactivity; Lung inflammation; Sensory nerves; C-FIBERS; SENSORY NEUROPEPTIDES; CHRONIC-BRONCHITIS; INFLAMMATION; RESPONSIVENESS; ASTHMA; MICE; DEGENERATION; EOSINOPHILIA; NEUROKININ;

D O I：

10.1016/j.micinf.2008.11.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Strongyloides venezuelensis migrates through the lungs and induces airway hyperresponsiveness (AHR). The present study evaluated the role of C-fibers in mediating airway inflammation and AHR after infection of rats with S. venezuelensis. Neonatal treatment with capsaicin effectively depleted sensory nerves. This was accompanied by inhibition of the AHR induced by S. venezuelensis infection. In contrast, capsaicin treatment greatly enhanced pulmonary inflammation, eosinophil influx and the local production of TNF-alpha. In conclusion, this is the first demonstration that, akin to viral and allergic AHR, permanent loss of sensory nerve C-fibers also reduces AHR induced by infection with a helminth. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：315 / 320

页数：6

共 29 条

[21] Changes in pulmonary function and parasite burden in rats infected with Strongyloides venezuelensis concomitant with induction of allergic airway inflammation [J].