Mechanisms of the airway hyperresponsiveness induced by Strongyloides venezuelensis infection in rats: role of capsaicin-sensitive neurons

被引：3

作者：

Ferreira, Caroline M. ^{[1
]}

Pereira, Ana-Terezinha M. ^{[2
]}

Amaral, Flavio A. ^{[1
]}

de Souza, Rafael S. ^{[1
]}

Coelho, Fernanda Matos ^{[1
]}

Souza, Danielle G. ^{[3
]}

Negrao-Correa, Deborah ^{[2
]}

Teixeira, Mauro M. ^{[1
]}

机构：

[1] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Bioquim & Imunol, BR-31270901 Belo Horizonte, MG, Brazil

[2] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Parasitol, BR-31270901 Belo Horizonte, MG, Brazil

[3] Univ Fed Minas Gerais, Inst Ciencias Biol, Dept Microbiol, BR-31270901 Belo Horizonte, MG, Brazil

来源：

MICROBES AND INFECTION | 2009年 / 11卷 / 02期

关键词：

Helminth; Airway hyperreactivity; Lung inflammation; Sensory nerves; C-FIBERS; SENSORY NEUROPEPTIDES; CHRONIC-BRONCHITIS; INFLAMMATION; RESPONSIVENESS; ASTHMA; MICE; DEGENERATION; EOSINOPHILIA; NEUROKININ;

D O I：

10.1016/j.micinf.2008.11.015

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

Strongyloides venezuelensis migrates through the lungs and induces airway hyperresponsiveness (AHR). The present study evaluated the role of C-fibers in mediating airway inflammation and AHR after infection of rats with S. venezuelensis. Neonatal treatment with capsaicin effectively depleted sensory nerves. This was accompanied by inhibition of the AHR induced by S. venezuelensis infection. In contrast, capsaicin treatment greatly enhanced pulmonary inflammation, eosinophil influx and the local production of TNF-alpha. In conclusion, this is the first demonstration that, akin to viral and allergic AHR, permanent loss of sensory nerve C-fibers also reduces AHR induced by infection with a helminth. (C) 2008 Elsevier Masson SAS. All rights reserved.

引用

页码：315 / 320

页数：6

共 29 条

[1] Immunomodulatory effects of sensory nerves during respiratory syncytial virus infection in rats [J].

Auais, A ;

Adkins, B ;

Napchan, G ;

Piedimonte, G .

AMERICAN JOURNAL OF PHYSIOLOGY-LUNG CELLULAR AND MOLECULAR PHYSIOLOGY, 2003, 285 (01) :L105-L113

[2] No audible wheezing: nuggets and conundrums from mouse asthma models [J].

Boyce, JA ;

Austen, KF .

JOURNAL OF EXPERIMENTAL MEDICINE, 2005, 201 (12) :1869-1873

[3]

BRENER Z., 1960, REV BRASIL BIOL, V20, P447

[4] Airway hyperresponsiveness in asthma: not just a matter of airway inflammation [J].

Brusasco, V ;

Crimi, E ;

Pellegrino, R .

THORAX, 1998, 53 (11) :992-998

[5]

BUIJS J, 1995, EUR J PHARM-ENVIRON, V293, P207, DOI 10.1016/S0922-4106(05)80045-8

[6]

Cremades Romero MJ, 1996, ARCH BRONCONEUMOL, V32, P430

[7] The involvement of sensory neuropeptides in airway hyper-responsiveness in rabbits sensitized and challenged to Parietaria judaica [J].

D'Agostino, B ;

Advenier, C ;

de Palma, R ;

Gallelli, L ;

Marrocco, G ;

Abbate, GF ;

Rossi, F .

CLINICAL AND EXPERIMENTAL ALLERGY, 2002, 32 (03) :472-479

[8] QUANTITATIVE LOCUS ANALYSIS OF AIRWAY HYPERRESPONSIVENESS IN A/J AND C57BL/6J MICE [J].

DESANCTIS, GT ;

MERCHANT, M ;

BEIER, DR ;

DREDGE, RD ;

GROBHOLZ, JK ;

MARTIN, TR ;

LANDER, ES ;

DRAZEN, JM .

NATURE GENETICS, 1995, 11 (02) :150-154

[9] Prevention of changes in airway function facilitates Strongyloides venezuelensis infection in rats [J].

Ferreira, Caroline M. ;

Pereira, Ana Terezinha M. ;

de Souza, Rafael S. ;

Cassali, Geovanni D. ;

Souza, Danielle G. ;

Lemos, Virginia S. ;

Teixeira, Mauro M. ;

Negrao-Correa, Deborah .

MICROBES AND INFECTION, 2007, 9 (07) :813-820

[10] Mechanisms involved in the enhancement of allergic airways neutrophil influx by permanent C-fiber degeneration in rats [J].

Franco-Penteado, CF ;

De Souza, IA ;

Camargo, EA ;

Teixeira, SA ;

Muscara, MN ;

De Nucci, G ;

Antunes, E .

JOURNAL OF PHARMACOLOGY AND EXPERIMENTAL THERAPEUTICS, 2005, 313 (01) :440-448

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