Optimization of Biopolymer Based Transdermal Films of Metoclopramide as an Alternative Delivery Approach

被引：20

作者：

Aktar, Betul ^{[1
]}

Erdal, Meryem Sedef ^{[1
]}

Sagirli, Olcay ^{[2
]}

Gungor, Sevgi ^{[1
]}

Ozsoy, Yildiz ^{[1
]}

机构：

[1] Istanbul Univ, Fac Pharm, Dept Pharmaceut Technol, TR-34116 Istanbul, Turkey

[2] Istanbul Univ, Fac Pharm, Dept Analyt Chem, TR-34116 Istanbul, Turkey

来源：

POLYMERS | 2014年 / 6卷 / 05期

关键词：

sodium alginate; natural polymers; metoclopramide; transdermal film; antiemetic drug; terpenes; ONSET INTRANASAL DELIVERY; IN-VITRO; PERCUTANEOUS-ABSORPTION; SKIN PERMEATION; MUCOADHESIVE PROPERTIES; SEMISOLID FORMULATIONS; PENETRATION ENHANCERS; GEL FORMULATIONS; STRATUM-CORNEUM; DOSAGE FORMS;

D O I：

10.3390/polym6051350

中图分类号：

O63 [高分子化学（高聚物）];

学科分类号：

070305 ; 080501 ; 081704 ;

摘要：

The objectives of this study were to develop and to characterize sodium alginate based matrix-type transdermal films of metoclopramide hydrochloride (MTC) in order to improve patient compliance to treatment. The suitability of sodium alginate was shown to be a natural film former in terms of the physicochemical, mechanical, and bioadhesive features of the MTC loaded transdermal films. Terpinolene provided the highest drug release among the different terpenes (nerolidol, eucalyptol, dl-limonene, or terpinolene) assessed as enhancer. Attenuated Total Reflectance Infrared (ATR-FTIR) spectroscopy analysis performed to evaluate the effect of the transdermal films on skin barrier confirmed enhancer induced lipid bilayer disruption in stratum corneum, indicating its permeation enhancement effect.

引用

页码：1350 / 1365

页数：16

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