Stereoselective synthesis of 15-and 16-substituted isosteviol derivatives and their cytotoxic activities

被引：53
作者：
Wu, Ya [1 ]
Dai, Gui-Fu [1 ]
Yang, Jing-Hua [1 ]
Zhang, Yun-Xiao [1 ]
Zhu, Yu [1 ]
Tao, Jing-Chao [1 ]
机构：
[1] Zhengzhou Univ, Dept Chem, New Drug Res & Dev Ctr, Daxue Rd 75, Zhengzhou 450052, Peoples R China
来源：
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS | 2009年 / 19卷 / 06期
基金：
中国国家自然科学基金;
关键词：
Isosteviol; 1,3-Diol; Stereoselective synthesis; 1,3-Dipolar cycloaddition; Cytotoxicity; DITERPENOIDS; STEVIOSIDE; ANALOGS;
D O I：
10.1016/j.bmcl.2008.12.101
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
By means of functional interconversions in ring D of the tetracyclic diterpene isosteviol (ent-16-ketobeyeran-19-oic acid 1), various 15- and 16-substituted isosteviol derivatives were stereoselectively prepared. The cytotoxic activities in vitro of these new isosteviol derivatives were investigated, and some of them showed noteworthy activities against B16-F10 melanoma cells. (C) 2009 Published by Elsevier Ltd.
引用
收藏
页码：1818 / 1821
页数：4
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