Alpha-mangostin promotes myoblast differentiation by modulating the gene-expression profile in C2C12 cells

被引：4
作者：
Horiba, Taro [1 ]
Katsukawa, Masahiro [1 ]
Abe, Keiko [2 ,3 ]
Nakai, Yuji [2 ]
机构：
[1] Kikkoman Foods Inc, Div Res & Dev, Noda, Chiba, Japan
[2] Univ Tokyo, Dept Appl Biol Chem, Grad Sch Agr & Life Sci, Bunkyo Ku, Tokyo, Japan
[3] Kanagawa Acad Sci & Technol, Life Sci & Environm Res Ctr, Kawasaki Ku, Kawasaki, Kanagawa, Japan
来源：
BIOSCIENCE BIOTECHNOLOGY AND BIOCHEMISTRY | 2014年 / 78卷 / 11期
关键词：
xanthone; myoblast; myotube; DNA microarray; alpha-mangostin; MYOSTATIN; BONE; FOLLISTATIN; XANTHONES; PATHWAY; PROTEIN;
D O I：
10.1080/09168451.2014.940832
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Alpha-mangostin, a xanthone contained mostly in mangosteen pericarp, has been reported to exert various biological functions. However, little is known about involvement of this xanthone in the muscle differentiation process. Here, we report the effect of alpha-mangostin on murine skeletal muscle-derived C2C12 myoblasts. alpha-mangostin stimulated myoblast differentiation leading to myotube formation. DNA microarray analysis revealed that genes associated with myoblast differentiation and muscle cell component formation were up-regulated in alpha-mangostin-treated cells. These results indicate that alpha-mangostin promotes myoblast differentiation through modulating the gene-expression profile in myoblasts.
引用
收藏
页码：1923 / 1929
页数：7
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