Two prospective studies found that elevated 2-hr glucose predicted male mortality independent of fasting glucose and HbAlc

被引:46
作者
Qiao, Q
Dekker, JM
de Vegt, F
Nijpels, G
Nissinen, A
Stehouwer, CDA
Bouter, LM
Heine, RJ
Tuomilehto, J
机构
[1] Natl Publ Hlth Inst, Diabet & Genet Epidemiol Unit, FIN-00300 Helsinki, Finland
[2] Univ Helsinki, Dept Publ Hlth, FIN-00300 Helsinki, Finland
[3] Vrije Univ Amsterdam, Med Ctr, Inst Res Extramural Med, NL-1081 BT Amsterdam, Netherlands
关键词
HbAlc; 2-hour glucose; fasting glucose; all-cause mortality;
D O I
10.1016/j.jclinepi.2003.10.007
中图分类号
R19 [保健组织与事业(卫生事业管理)];
学科分类号
摘要
Objective: To quantify the relative contribution of elevated 2-hr glucose, fasting glucose (FPG), and HbA1c to all-cause mortality. Study Design and Setting: A joint analysis of two prospective studies with baseline glycemia measurements. Results: The multivariate adjusted hazard ratios (HRs) corresponding to a one standard deviation increase in HbA1c were 1.14 (95% CI 1.03-1.25), 1.08 (0.98-1.19) for FPG and 1.15 (1.05-1.27) for 2-hr glucose, respectively. Entering the 2-hr glucose to the model based on the FPG and HbA1c significantly improved the prediction of mortality, whereas neither FPG, nor HbA1c added significant information once 2-hr glucose was in the models. In subjects with FPG <7.0 mmol/L and HbA1c less than or equal to6.5%, the HR was 1.35 (1.03-1.78) in men with 2-hr glucose greater than or equal to7.8 mmol/L compared with men with 2-hr glucose <7.8 mmol/L. Conclusion: Elevated 2-hr glucose was a predictor of mortality independent of the levels of fasting glucose and HbA1c. (C) 2004 Elsevier Inc. All rights reserved.
引用
收藏
页码:590 / 596
页数:7
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